Department of Chemistry and Centro de Innovación en Quı́mica Avanzada (ORFEO-CINQA), Faculty of Sciences, Carrer dels Til.lers, UAB Campus, Universitat Autònoma de Barcelona, 08193 Cerdanyola del Vallès, Barcelona, Spain.
Departament de Biologia Cel·lular, Fisiologia i Immunologia and Institut de Neurociències, Universitat Autònoma de Barcelona, Campus UAB, 08193 Cerdanyola del Vallès, Barcelona, Spain.
ACS Appl Mater Interfaces. 2020 Jun 10;12(23):25658-25675. doi: 10.1021/acsami.0c06629. Epub 2020 May 28.
The preparation of functional cotton fabrics and silica nanoparticles by direct covalent linking of nonsteroidal anti-inflammatory drugs (salicylic acid, ibuprofen, and diclofenac) through an amide group is reported. Moreover, the coating of cotton fabrics with silica nanoparticles functionalized with such antiinflamatory agents is found to increase the roughness of the surface, providing hydrophobicity to the modified fabrics. This property is enhanced by the addition of fluorinated alkyl silane in the co-condensation process to form the coating solution. Characterization of the functionalized nanoparticles and cotton textiles is accomplished by microscopic and spectroscopic techniques. The treatment of functionalized nanoparticles and cotton fabrics with model proteases and leukocytes from animal origin results in the release of the drug by the selective enzymatic cleavage of the amide bond. Topical cutaneous applications in wound dressings and cream formulations for the acceleration of wound healing are envisaged.
通过酰胺基团将非甾体抗炎药物（水杨酸、布洛芬和双氯芬酸）直接共价连接到功能棉织物和硅纳米粒子上的方法已经被报道。此外，通过将具有抗炎药物官能化的硅纳米粒子涂覆到棉织物上，发现可以增加表面的粗糙度，使改性织物具有疏水性。通过在共缩合过程中添加氟化烷基硅烷，可以增强这种性质，从而形成涂覆溶液。通过微观和光谱技术对功能化纳米粒子和棉纺织品进行了表征。用模型蛋白酶和动物来源的白细胞处理功能化纳米粒子和棉织物，通过酰胺键的选择性酶切导致药物释放。设想将其用于伤口敷料和乳膏制剂的局部皮肤应用，以加速伤口愈合。
