Ely Matthew R, Ratchford Stephen M, La Salle D Taylor, Trinity Joel D, Wray D Walter, Halliwill John R
Department of Human Physiology, University of Oregon, Eugene, Oregon.
Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, Salt Lake City, Utah.
J Appl Physiol (1985). 2020 Jun 1;128(6):1626-1634. doi: 10.1152/japplphysiol.00689.2019. Epub 2020 May 14.
Histamine mediates vasodilation during inflammatory and immune responses, as well as following endurance exercise. During exercise, intramuscular histamine concentration increases, and its production, appears related to exercise intensity and duration. However, whether histamine contributes to exercise hyperemia and promotes exercise blood flow in an intensity- or duration-dependent pattern is unknown. The purpose of this study was to compare leg blood flow across a range of exercise intensities, before and after prolonged exercise, with and without histamine-receptor antagonism. It was hypothesized that combined oral histamine H/H-receptor antagonism would decrease leg blood flow, and the effect would be greater at higher intensities and following prolonged exercise. Sixteen (7F, 9M) volunteers performed single-leg knee-extension exercise after consuming either placebo or combined histamine H/H-receptor antagonists (Blockade). Exercise consisted of two graded protocols at 20, 40, 60, and 80% of peak power, separated by 60 min of knee-extension exercise at 60% of peak power. Femoral artery blood flow was measured by ultrasonography. Femoral artery blood flow increased with exercise intensity up to 2,660 ± 97 mL/min at 80% of peak power during Placebo ( < 0.05). Blood flow was further elevated with Blockade to 2,836 ± 124 mL/min ( < 0.05) at 80% peak power (9.1 ± 4.8% higher than placebo). These patterns were not affected by prolonged exercise ( = 0.13). On average, femoral blood flow during prolonged exercise was 12.7 ± 2.8% higher with Blockade vs. Placebo ( < 0.05). Contrary to the hypothesis, these results suggest that histamine receptor antagonism during exercise, regardless of intensity or duration, increases leg blood flow measured by ultrasonography. Leg blood flow during exercise was increased by taking antihistamines, which block the receptors for histamine, a molecule often associated with inflammatory and immune responses. The elevated blood flow occurred over exercise intensities ranging from 20 to 80% of peak capacity and during exercise of 60 min duration. These results suggest that exercise-induced elevations in histamine concentrations are involved in novel, poorly understood, and perhaps complex ways in the exercise response.
组胺在炎症和免疫反应期间以及耐力运动后介导血管舒张。在运动过程中，肌肉内组胺浓度会升高，其产生似乎与运动强度和持续时间有关。然而，组胺是否以强度或持续时间依赖性模式促进运动性充血并增加运动血流量尚不清楚。本研究的目的是比较在长时间运动前后，在有和没有组胺受体拮抗作用的情况下，一系列运动强度下的腿部血流量。研究假设口服组胺H₁/H₂受体联合拮抗剂会减少腿部血流量，且在更高强度和长时间运动后效果会更明显。16名志愿者（7名女性，9名男性）在服用安慰剂或组胺H₁/H₂受体联合拮抗剂（阻断组）后进行单腿伸膝运动。运动包括两个分级方案，分别在峰值功率的20%、40%、60%和80%进行，中间间隔60分钟在峰值功率60%的伸膝运动。通过超声测量股动脉血流量。在安慰剂组中，股动脉血流量随着运动强度增加，在峰值功率80%时达到2660±97毫升/分钟（P<0.05）。在阻断组中，在峰值功率80%时血流量进一步升高至2836±124毫升/分钟（P<0.05）（比安慰剂组高9.1±4.8%）。这些模式不受长时间运动的影响（P=0.13）。平均而言，在长时间运动期间，阻断组的股血流量比安慰剂组高12.7±2.8%（P<0.05）。与假设相反，这些结果表明运动期间的组胺受体拮抗作用，无论强度或持续时间如何，都会增加通过超声测量的腿部血流量。服用阻断组胺受体的抗组胺药会增加运动期间的腿部血流量，组胺是一种常与炎症和免疫反应相关的分子。血流量升高发生在峰值能力的20%至80%的运动强度范围内以及60分钟的运动期间。这些结果表明，运动诱导的组胺浓度升高以新颖、鲜为人知且可能复杂的方式参与运动反应。
