Neurovascular Physiology Laboratory, School of Kinesiology, Auburn University, Auburn, Alabama.
Women's Cardiovascular Research Laboratory, Department of Kinesiology and Applied Physiology, University of Delaware, Newark, Delaware.
Am J Physiol Heart Circ Physiol. 2022 Jan 1;322(1):H66-H70. doi: 10.1152/ajpheart.00556.2021. Epub 2021 Nov 19.
In recent years, the traditional, unspoken assumption in published biomedical research studies that the young, healthy (usually white) male is the "default human" has received increasing scrutiny and criticism. The historical underrepresentation of female participants in biomedical research has been increasingly recognized and addressed, including with the current call for papers at the . Our goal in the present Perspectives is to discuss the topic of terminology (man/woman vs. male/female) for human research participants when considering sex as a biological variable. This important consideration is consistent with the importance of gender identity and related topics to psychological, emotional, and physical health. Just as pronouns are important, so is appropriate terminology when referring to human research volunteers. Despite some disagreement regarding terminology between our two groups of authors, we provide consensus recommendations. Importantly, we all agree that the most vital aspect of the present discussion is the broader focus on sex as a biological variable and appropriate inclusion of biological sex in in vitro, preclinical, and human research studies.
近年来，已发表的生物医学研究论文中存在一个传统的、默认为真的假设，即年轻、健康（通常为白人）的男性是“默认的人类”，这一假设受到了越来越多的审查和批评。生物医学研究中女性参与者代表性不足的问题已逐渐得到认识和解决，包括目前在 上发表论文的要求。我们在本观点中讨论的是，当考虑性别作为生物学变量时，研究参与者的术语（男性/女性与男性/女性）。这一重要的考虑因素与性别认同及相关主题对心理、情感和身体健康的重要性一致。正如代词很重要一样，在提到人类研究志愿者时使用适当的术语也很重要。尽管我们两位作者组之间在术语上存在一些分歧，但我们提供了一致的建议。重要的是，我们都同意，目前讨论的更重要方面是将性别作为生物学变量的更广泛关注，以及在体外、临床前和人体研究中适当纳入生物学性别。
