Retina and Uveitis Services, L V Prasad Eye Institute (MTC Campus), Bhubaneswar, India.
Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Ocul Immunol Inflamm. 2021 Nov 17;29(7-8):1513-1519. doi: 10.1080/09273948.2020.1746358. Epub 2020 May 14.
The pathogenesis of ocular tuberculosis (TB) has remained unclear due to the challenges of performing mechanistic studies on clinical samples. Animal models have the potential to bridge these gaps by providing information about ocular dissemination and localization of mycobacteria, innate and adaptive immune response, and granuloma formation in the eye. Here, we critically review various animal models of ocular TB from the early 20 century to date and derive novel insights into pathogenesis of ocular TB that have direct implications on the diagnosis and treatment of this disease. Future directions on experimental approaches to understanding pathogenesis of ocular TB are also discussed.
由于在临床样本上进行机制研究存在挑战，眼部结核病（TB）的发病机制仍不清楚。动物模型具有提供有关分枝杆菌在眼部的传播和定位、先天和适应性免疫反应以及眼部肉芽肿形成的信息的潜力，从而弥补了这些空白。在这里，我们批判性地回顾了从 20 世纪初至今的各种眼部 TB 动物模型，并深入了解了眼部 TB 的发病机制，这对该疾病的诊断和治疗具有直接影响。还讨论了理解眼部 TB 发病机制的实验方法的未来方向。
