Hyperreactivity of platelets to serotonin (5-hydroxytryptamine) in patients with cardiovascular diseases. Influence of ketanserin, a serotonin S2-receptor antagonist.

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作者信息

De Crée J, Roels V, Verhaegen H

机构信息

Clinical Research Unit St Bartholomeus, Jan Palfijn Hospital, Merksem, Belgium.

出版信息

Drugs. 1988;36 Suppl 1:87-91. doi: 10.2165/00003495-198800361-00015.

DOI:10.2165/00003495-198800361-00015

PMID:3240733

Abstract

摘要

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Ketanserin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in hypertension and peripheral vascular disease.酮色林。对其药效学和药代动力学特性以及在高血压和外周血管疾病中的治疗潜力的综述。

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Effect of encainide, ODE, MODE, and flecainide on ADP/5-HT induced platelet aggregation and in the anesthetized dog coronary artery stenosis-occlusion model of intravascular thrombosis.恩卡尼、ODE、MODE和氟卡尼对二磷酸腺苷/5-羟色胺诱导的血小板聚集以及在麻醉犬冠状动脉狭窄-闭塞性血管内血栓形成模型中的作用。

Cardiovasc Drugs Ther. 1991 Aug;5(4):763-8. doi: 10.1007/BF03029752.

本文引用的文献

Platelet aggregates in ischemic heart disease.缺血性心脏病中的血小板聚集体

Thromb Haemost. 1980 Jul 15;43(3):185-8.

Platelet-mediated vascular contractions: inhibition of the serotonergic component by ketanserin.血小板介导的血管收缩：酮色林对5-羟色胺成分的抑制作用。

Thromb Res. 1982 Sep 15;27(6):713-27. doi: 10.1016/0049-3848(82)90009-3.

Platelets and prostaglandins in coronary artery disease. Rationale for use of platelet-suppressive drugs.

JAMA. 1983 May 27;249(20):2818-23.

Receptor binding profile of R 41 468, a novel antagonist at 5-HT2 receptors.新型5-羟色胺2受体拮抗剂R 41 468的受体结合情况

Life Sci. 1981 Mar 2;28(9):1015-22. doi: 10.1016/0024-3205(81)90747-5.

Placebo-controlled double-blind trial of ketanserin in treatment of intermittent claudication.

Lancet. 1984 Oct 6;2(8406):775-9. doi: 10.1016/s0140-6736(84)90704-9.

A biphasic response of platelets to serotonin.血小板对血清素的双相反应。

Scand J Haematol. 1970;7(3):145-51. doi: 10.1111/j.1600-0609.1970.tb01881.x.

Adenosine diphosphate induced platelet aggregation in myocardial infarction and ischemic heart disease.

Atherosclerosis. 1973 Jan-Feb;17(1):107-20. doi: 10.1016/0021-9150(73)90139-1.

Serotoninergic mechanisms in hypertension. Focus on the effects of ketanserin.高血压中的5-羟色胺能机制。聚焦于酮色林的作用。

Hypertension. 1988 Feb;11(2):111-33. doi: 10.1161/01.hyp.11.2.111.

The effect of ketanserin, a 5-HT2-receptor antagonist, on 5-hydroxytryptamine-induced irreversible platelet aggregation in patients with cardiovascular diseases.

Agents Actions. 1985 Jul;16(5):313-7. doi: 10.1007/BF01982865.

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