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Optimizing Chimeric Antigen Receptor T-Cell Therapy for Adults With Acute Lymphoblastic Leukemia.优化嵌合抗原受体 T 细胞疗法治疗成人急性淋巴细胞白血病。
J Clin Oncol. 2020 Feb 10;38(5):415-422. doi: 10.1200/JCO.19.01892. Epub 2019 Dec 9.
2
CAR-T-cell neurotoxicity: hope is on the horizon.嵌合抗原受体T细胞神经毒性：曙光在前。
Blood. 2019 May 16;133(20):2114-2116. doi: 10.1182/blood-2019-03-900985.
3
Clinical presentation, management, and biomarkers of neurotoxicity after adoptive immunotherapy with CAR T cells.嵌合抗原受体 T 细胞过继免疫治疗后的神经毒性的临床表现、治疗和生物标志物。
Blood. 2019 May 16;133(20):2212-2221. doi: 10.1182/blood-2018-12-893396. Epub 2019 Feb 26.
4
CAR T-Cell Associated Neurotoxicity: Mechanisms, Clinicopathologic Correlates, and Future Directions.嵌合抗原受体 T 细胞相关神经毒性：机制、临床病理相关性及未来方向。
J Natl Cancer Inst. 2019 Jul 1;111(7):646-654. doi: 10.1093/jnci/djz017.
5
ASTCT Consensus Grading for Cytokine Release Syndrome and Neurologic Toxicity Associated with Immune Effector Cells.ASTCT 细胞因子释放综合征和免疫效应细胞相关神经系统毒性的共识分级标准。
Biol Blood Marrow Transplant. 2019 Apr;25(4):625-638. doi: 10.1016/j.bbmt.2018.12.758. Epub 2018 Dec 25.
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Clinical and Biological Correlates of Neurotoxicity Associated with CAR T-cell Therapy in Patients with B-cell Acute Lymphoblastic Leukemia.与 B 细胞急性淋巴细胞白血病患者的 CAR T 细胞治疗相关的神经毒性的临床和生物学相关性。
Cancer Discov. 2018 Aug;8(8):958-971. doi: 10.1158/2159-8290.CD-17-1319. Epub 2018 Jun 7.
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Monocyte-derived IL-1 and IL-6 are differentially required for cytokine-release syndrome and neurotoxicity due to CAR T cells.单核细胞衍生的白细胞介素-1 和白细胞介素-6 对于 CAR T 细胞引起的细胞因子释放综合征和神经毒性是有差异需求的。
Nat Med. 2018 Jun;24(6):739-748. doi: 10.1038/s41591-018-0036-4. Epub 2018 May 28.
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Fludarabine and neurotoxicity in engineered T-cell therapy.氟达拉滨与基因工程 T 细胞治疗的神经毒性。
Gene Ther. 2018 Jun;25(3):176-191. doi: 10.1038/s41434-018-0019-6. Epub 2018 May 7.
9
Biomarkers of cytokine release syndrome and neurotoxicity related to CAR-T cell therapy.与嵌合抗原受体T细胞疗法相关的细胞因子释放综合征和神经毒性的生物标志物。
Biomark Res. 2018 Jan 22;6:4. doi: 10.1186/s40364-018-0116-0. eCollection 2018.
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JCAR015 in ALL: A Root-Cause Investigation.急性淋巴细胞白血病中JCAR015的根本原因调查。
Cancer Discov. 2018 Jan;8(1):4-5. doi: 10.1158/2159-8290.CD-NB2017-169. Epub 2017 Dec 5.

Intrathecal chemotherapy for management of steroid-refractory CAR T-cell-associated neurotoxicity syndrome.

作者信息

Shah Nirav N, Johnson Bryon D, Fenske Timothy S, Raj Renju V, Hari Parameswaran

机构信息

Division of Hematology/Oncology, Medical College of Wisconsin, Milwaukee, WI; and.

Avera Hematology and Bone Marrow Transplant, Avera McKennan Hospital and University Health Center, Sioux Falls, SD.

出版信息

Blood Adv. 2020 May 26;4(10):2119-2122. doi: 10.1182/bloodadvances.2020001626.

DOI:10.1182/bloodadvances.2020001626
PMID:32407473
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7252557/
Abstract
摘要