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Does the Fc Region Have a Role in the Ocular Half-life After Intravitreal Injection?

作者信息

Caruso Antonello, Mazer Norman A

机构信息

, , . E-mail: .

出版信息

Invest Ophthalmol Vis Sci. 2020 May 11;61(5):20. doi: 10.1167/iovs.61.5.20.

DOI:10.1167/iovs.61.5.20
PMID:32407522
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7405609/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d28b/7405609/b8480adf9736/iovs-61-5-20-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d28b/7405609/b8480adf9736/iovs-61-5-20-f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d28b/7405609/b8480adf9736/iovs-61-5-20-f001.jpg

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引用本文的文献

1
Author Response: Does the Fc Region Have a Role in the Ocular Half-Life After Intravitreal Injection?作者回复:Fc区域在玻璃体内注射后的眼内半衰期是否起作用?
Invest Ophthalmol Vis Sci. 2020 May 11;61(5):21. doi: 10.1167/iovs.61.5.21.

本文引用的文献

1
Role of the Fc Region in the Vitreous Half-Life of Anti-VEGF Drugs.Fc区在抗VEGF药物玻璃体内半衰期中的作用
Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):4261-4267. doi: 10.1167/iovs.17-21813.
2
Ocular Pharmacokinetics of Therapeutic Antibodies Given by Intravitreal Injection: Estimation of Retinal Permeabilities Using a 3-Compartment Semi-Mechanistic Model.玻璃体内注射治疗性抗体的眼药代动力学:使用三室半机制模型估算视网膜通透性
Mol Pharm. 2017 Aug 7;14(8):2690-2696. doi: 10.1021/acs.molpharmaceut.7b00164. Epub 2017 Jul 3.
3
A mechanistic pharmacokinetic/pharmacodynamic model of factor D inhibition in cynomolgus monkeys by lampalizumab for the treatment of geographic atrophy.
兰帕利单抗治疗地图样萎缩在食蟹猴中抑制因子D的机制性药代动力学/药效学模型。
J Pharmacol Exp Ther. 2015 Nov;355(2):288-96. doi: 10.1124/jpet.115.227223.
4
Design and Pharmacokinetic Characterization of Novel Antibody Formats for Ocular Therapeutics.用于眼部治疗的新型抗体形式的设计与药代动力学特性
Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5390-400. doi: 10.1167/iovs.15-17108.
5
Pharmacokinetics.药代动力学。
Biochem Pharmacol. 2014 Jan 1;87(1):93-120. doi: 10.1016/j.bcp.2013.09.007. Epub 2013 Sep 17.