Hasegawa N, Imaizumi Y, Watanabe M
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
Eur J Pharmacol. 1988 Nov 1;156(2):291-4. doi: 10.1016/0014-2999(88)90336-6.
An anomalous change in response to exogenously applied acetylcholine (ACh) was found in the rat iris dilator muscle after surgical parasympathetic denervation. The relaxation induced by nerve stimulation in the normal dilator muscles disappeared after the denervation. ACh elicited relaxation and contraction at low (less than 3 X 10(-6) M) and higher doses, respectively, in the normal muscles. The relaxing response to ACh was almost abolished after the denervation, while the maximum contractile response to ACh was not affected significantly.
在手术切断副交感神经后，发现大鼠虹膜开大肌对外源性应用乙酰胆碱（ACh）的反应出现异常变化。正常开大肌中神经刺激所诱导的舒张在去神经后消失。在正常肌肉中，ACh在低剂量（小于3×10⁻⁶ M）时引起舒张，而在高剂量时引起收缩。去神经后，对ACh的舒张反应几乎完全消失，而对ACh的最大收缩反应未受到显著影响。
