Sato T, Miyai T, Akaike I, Togashi M, Kojima M, Okamoto M
Drug Development Laboratories, CHUGAI Pharmaceutical Co., Ltd., Tokyo, Japan.
Jikken Dobutsu. 1988 Oct;37(4):375-80. doi: 10.1538/expanim1978.37.4_375.
A mouse representing a new hereditary cataract strain was found in a mouse colony and a new line was established strain CSM. These mice were investigated genetically, histologically and biochemically. The results suggested that this cataract was apparently inherited through two recessive autosomal genes. Histologically the denucleation process of lens fibers was abnormal and small vacuoles appeared in the equatorial region of the lens cortex at 12 days. Biochemically, insoluble protein and sodium increased in the lens with age.
在一个小鼠种群中发现了一只代表新的遗传性白内障品系的小鼠，并建立了新的CSM品系。对这些小鼠进行了遗传学、组织学和生物化学研究。结果表明，这种白内障显然是通过两个隐性常染色体基因遗传的。组织学上，晶状体纤维的去核过程异常，在12天时晶状体皮质的赤道区域出现小空泡。生物化学方面，晶状体中不溶性蛋白质和钠随年龄增加。
