Yoneda Hisami, Shimizu Yoshiko, Masuda Ryo
Dept. of Breast Surgery, Japanese Red Cross Medical Center.
Gan To Kagaku Ryoho. 2020 May;47(5):815-818.
A 70-year-old woman was diagnosed with cT2N2M0 left triple negative breast cancer. She received neoadjuvant chemotherapy. Around 30 months after the surgery, she developed carcinomatous pericardial tamponade, carcinomatous pleurisy, and metastatic thyroid cancer due to the breast cancer. Around the same time, a BRCA2 mutation was confirmed. Thus, olaparib therapy was started. Around 45 days after the start of olaparib administration, the therapeutic effect was cPR. The treatment remains effective even after approximately 1 year.
一名70岁女性被诊断为cT2N2M0期左侧三阴性乳腺癌。她接受了新辅助化疗。术后约30个月，她因乳腺癌出现癌性心包填塞、癌性胸膜炎和转移性甲状腺癌。大约在同一时间，证实存在BRCA2突变。因此，开始使用奥拉帕利治疗。奥拉帕利给药开始后约45天，治疗效果为完全缓解（cPR）。即使在大约1年后，治疗仍然有效。
