Department of Biomedical Engineering, Southern University of Science and Technology, No. 1088 Xueyuan Rd, Nanshan District, Shenzhen, Guangdong 518055, P. R. China.
Chem Commun (Camb). 2020 Jun 18;56(49):6664-6667. doi: 10.1039/d0cc02077j.
We report benzeneselenol-modified gold nanoclusters (Se_Au NCs) that have significant anticancer activity by inducing autophagy and disassembly of F-actin in cancer cells. Upon treatment of different tumor models on mice, it has been found that Se_Au NCs exhibit excellent antitumor efficacy, high stability, and extremely low toxicity, which are the requirements for an ideal antineoplastic drug. Our study is a successful attempt in exploring novel anticancer agents with high biosafety.
我们报告了苯硒醇修饰的金纳米簇（Se_Au NCs），通过诱导自噬和破坏癌细胞中的 F-肌动蛋白，具有显著的抗癌活性。在对小鼠的不同肿瘤模型进行治疗后，发现 Se_Au NCs 表现出优异的抗肿瘤疗效、高稳定性和极低的毒性，这些都是理想的抗肿瘤药物的要求。我们的研究是探索具有高生物安全性的新型抗癌剂的成功尝试。
