Dan Hao, Yanmei Li, Yue Xiao, Xian Jiang
Department of Dermatology and Venereology, West China Hospital, SiChuan University, SiChuan, P.R. China.
Dermatol Ther. 2020 Jul;33(4):e13588. doi: 10.1111/dth.13588. Epub 2020 Jul 5.
Sweet syndrome (SS), also known as acute febrile neutrophilic dermatosis, is a rare inflammatory disorder characterized by sudden onset of variably tender brightly erythematous-to-violaceous papules, plaques, or nodules. To clarify the frequency, clinical course, therapeutic response, and outcome of Sweet syndrome with malignancy. We conducted a retrospective review of patients diagnosed with SS between 2009 and 2019 with a diagnosis of Sweet syndrome in West China hospital. Records were analyzed for variables, clinical features, etiological factors, laboratory results, and treatment outcomes. The 25 cases under study consisted of 14 (56%) females and 11 (44%) males. Mean age was 52.2 years (range: 4-76 years). Nodules were the commonest lesion presentation (48%), involving mostly the lower limbs (52%). Pain of lesion was identified as the most common symptom (88%), followed by fever (76%) and cough (44%). Among the patients, 52% exhibited the classic form, 48% showed the malignancy-associated form, and 4% exhibited the drug-induced form in the setting of malignancy. Acute myeloid leukemia was the most common malignancy, observed in 5 of 12 patients (41.6%). Anemia (P = .002) was associated with malignancy (Chi-square test).
Sweet综合征（SS），又称急性发热性嗜中性皮病，是一种罕见的炎症性疾病，其特征为突然出现大小不一的压痛性鲜红色至紫红色丘疹、斑块或结节。为了阐明合并恶性肿瘤的Sweet综合征的发病率、临床病程、治疗反应及预后。我们对2009年至2019年期间在华西医院诊断为Sweet综合征的患者进行了一项回顾性研究。分析记录中的变量、临床特征、病因、实验室检查结果及治疗结果。研究的25例患者中，女性14例（56%），男性11例（44%）。平均年龄为52.2岁（范围：4 - 76岁）。结节是最常见的皮损表现（48%），主要累及下肢（52%）。皮损疼痛是最常见的症状（88%），其次是发热（76%）和咳嗽（44%）。在这些患者中，52%表现为经典型，48%为合并恶性肿瘤型，4%为在恶性肿瘤背景下的药物诱发型。急性髓系白血病是最常见的恶性肿瘤，12例患者中有5例（41.6%）。贫血（P = .002）与恶性肿瘤相关（卡方检验）。
