Laboratory of Myeloid Cell Heterogeneity and Function, VIB-UGent Center for Inflammation Research, Ghent, Belgium.
Department of Biomedical Molecular Biology, Faculty of Science, Ghent University, Ghent, Belgium.
Front Endocrinol (Lausanne). 2020 Apr 29;11:259. doi: 10.3389/fendo.2020.00259. eCollection 2020.
The increasing prevalence of obesity is accompanied by a rising incidence in metabolic syndrome and related pathologies such as non-alcoholic fatty liver disease. Macrophages are hypothesized to play central roles in these diseases, through their role as inflammatory mediators and as such are thought to be potential targets for future therapies. Recently, single cell technologies have revealed significant heterogeneity within the macrophage pool in both liver and adipose tissue in obesity. Thus current efforts are focused on dissecting this heterogeneity and understanding the distinct functions of the individual subsets. In this review, we discuss the current knowledge regarding macrophage heterogeneity, ontogeny and functions in the context of obese adipose tissue and fatty liver disease and attempt to align the distinct populations described to date.
肥胖症的发病率不断上升，伴随着代谢综合征和相关疾病的发病率上升，如非酒精性脂肪性肝病。巨噬细胞被认为在这些疾病中发挥核心作用，通过其作为炎症介质的作用，被认为是未来治疗的潜在靶点。最近，单细胞技术揭示了肥胖症肝和脂肪组织中巨噬细胞池内的显著异质性。因此，目前的努力集中在剖析这种异质性并理解各个亚群的独特功能。在这篇综述中，我们讨论了目前关于肥胖症脂肪组织和脂肪肝疾病中巨噬细胞异质性、发生和功能的知识，并试图将迄今为止描述的不同群体进行匹配。
