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博来霉素诱导的隐源性机化性肺炎表现为一名经典精原细胞瘤患者的自发性气胸。

Bleomycin-Induced Cryptogenic Organizing Pneumonia Manifested as Spontaneous Pneumothorax in a Patient with Classic Seminoma.

作者信息

Ortíz-Farías Diana Lizbeth, López-Romero Stephanie, Barrera-Pérez Hirian Alonso Moshe, Vargas-Mendoza Gary Kosai, Cortes-Telles Arturo

机构信息

Departamento de Neumología y Cirugía de Tórax. Hospital Regional de Alta Especialidad de la Península de Yucatán.

Anatomía Patológica ANAPAT. Mérida, Yucatán, México.

出版信息

Tanaffos. 2019 Mar;18(3):268-271.

PMID:32411268
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7210568/
Abstract

Cryptogenic Organizing Pneumonia (COP) can manifest like a collagen disorder or infectious diseases, or be caused by drug induced toxicity. This paper presents the case of a 24 year-old man diagnosed with classic seminoma, treated with chemotherapy scheme that included bleomycin (accumulated dose, 120 units). The patient was admitted at the hospital due to rapidly-progressing dyspnea and thoracic pain. The diagnostic approach revealed the presence of a spontaneous pneumothorax, while a lung biopsy documented COP. Despite treatment, the patient died from disease progression.

摘要

隐源性机化性肺炎(COP)可表现得像胶原病或传染病,或由药物诱导的毒性引起。本文介绍了一名24岁男性的病例,该患者被诊断为经典型精原细胞瘤,接受了包含博来霉素(累积剂量为120单位)的化疗方案。患者因迅速进展的呼吸困难和胸痛入院。诊断方法显示存在自发性气胸,而肺活检记录为COP。尽管进行了治疗,患者仍因疾病进展而死亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44a6/7210568/46242e1c11c8/Tanaffos-18-268-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44a6/7210568/625e184508f7/Tanaffos-18-268-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44a6/7210568/46242e1c11c8/Tanaffos-18-268-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44a6/7210568/625e184508f7/Tanaffos-18-268-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/44a6/7210568/46242e1c11c8/Tanaffos-18-268-g002.jpg

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本文引用的文献

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Cryptogenic organising pneumonia presenting with spontaneous pneumothorax and the value of procalcitonin: A case report.以自发性气胸为表现的隐源性机化性肺炎及降钙素原的价值:一例报告
Respir Med Case Rep. 2017 Jun 10;22:36-38. doi: 10.1016/j.rmcr.2017.06.006. eCollection 2017.
2
Effect of Bleomycin Administration on the Development of Pulmonary Toxicity in Patients With Metastatic Germ Cell Tumors Receiving First-Line Chemotherapy: A Meta-Analysis of Randomized Studies.博来霉素给药对接受一线化疗的转移性生殖细胞肿瘤患者发生肺毒性的影响:一项随机研究的荟萃分析
Clin Genitourin Cancer. 2017 Apr;15(2):213-220.e5. doi: 10.1016/j.clgc.2016.08.021. Epub 2016 Sep 8.
3
The role of screening and monitoring for bleomycin pulmonary toxicity.
博来霉素肺毒性的筛查与监测作用
J Oncol Pharm Pract. 2016 Apr;22(2):308-12. doi: 10.1177/1078155215574294. Epub 2015 Mar 2.
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Spontaneous pneumothorax: epidemiology, pathophysiology and cause.自发性气胸:流行病学、病理生理学和病因。
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Cryptogenic organising pneumonia.隐源性机化性肺炎
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Pulmonary toxicity of chemotherapy.化疗的肺部毒性
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