博来霉素诱导的隐源性机化性肺炎表现为一名经典精原细胞瘤患者的自发性气胸。

Bleomycin-Induced Cryptogenic Organizing Pneumonia Manifested as Spontaneous Pneumothorax in a Patient with Classic Seminoma.

作者信息

Ortíz-Farías Diana Lizbeth, López-Romero Stephanie, Barrera-Pérez Hirian Alonso Moshe, Vargas-Mendoza Gary Kosai, Cortes-Telles Arturo

机构信息

Departamento de Neumología y Cirugía de Tórax. Hospital Regional de Alta Especialidad de la Península de Yucatán.

Anatomía Patológica ANAPAT. Mérida, Yucatán, México.

出版信息

Tanaffos. 2019 Mar;18(3):268-271.

PMID:32411268

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7210568/

Abstract

Cryptogenic Organizing Pneumonia (COP) can manifest like a collagen disorder or infectious diseases, or be caused by drug induced toxicity. This paper presents the case of a 24 year-old man diagnosed with classic seminoma, treated with chemotherapy scheme that included bleomycin (accumulated dose, 120 units). The patient was admitted at the hospital due to rapidly-progressing dyspnea and thoracic pain. The diagnostic approach revealed the presence of a spontaneous pneumothorax, while a lung biopsy documented COP. Despite treatment, the patient died from disease progression.

摘要

隐源性机化性肺炎（COP）可表现得像胶原病或传染病，或由药物诱导的毒性引起。本文介绍了一名24岁男性的病例，该患者被诊断为经典型精原细胞瘤，接受了包含博来霉素（累积剂量为120单位）的化疗方案。患者因迅速进展的呼吸困难和胸痛入院。诊断方法显示存在自发性气胸，而肺活检记录为COP。尽管进行了治疗，患者仍因疾病进展而死亡。