Centre of Stomatology, Xiangya Hospital, Central South University, Changsha 410008, China.
Department of Thoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Oxid Med Cell Longev. 2020 Apr 28;2020:2415324. doi: 10.1155/2020/2415324. eCollection 2020.
Oxidative stress refers to an imbalance between reactive oxygen species (ROS) generation and body's capability to detoxify the reactive mediators or to fix the relating damage. MicroRNAs are considered to be important mediators that play essential roles in the regulation of diverse aspects of carcinogenesis. Growing studies have demonstrated that the ROS can regulate microRNA biogenesis and expression mainly through modulating biogenesis course, transcription factors, and epigenetic changes. On the other hand, microRNAs may in turn modulate the redox signaling pathways, altering their integrity, stability, and functionality, thus contributing to the pathogenesis of multiple diseases. Both ROS and microRNAs have been identified to be important regulators and potential therapeutic targets in cancers. However, the information about the interplay between oxidative stress and microRNA regulation is still limited. The present review is aimed at summarizing the current understanding of molecular crosstalk between microRNAs and the generation of ROS in the pathogenesis of cancer.
氧化应激是指活性氧（ROS）的产生与机体解毒活性介质或修复相关损伤的能力之间失去平衡。microRNAs 被认为是重要的调节因子，在肿瘤发生的多个方面的调控中发挥着重要作用。越来越多的研究表明，ROS 可以通过调节生物发生过程、转录因子和表观遗传改变来调节 microRNA 的生物发生和表达。另一方面，microRNAs 也可以反过来调节氧化还原信号通路，改变其完整性、稳定性和功能，从而导致多种疾病的发病机制。ROS 和 microRNAs 都被确定为癌症的重要调节因子和潜在治疗靶点。然而，关于氧化应激与 microRNA 调控之间相互作用的信息仍然有限。本综述旨在总结目前对 microRNAs 与 ROS 在癌症发病机制中的生成之间的分子相互作用的理解。
