Departamento de Quı́mica Inorgánica, Facultad de Ciencias Quı́micas, Universidad Complutense de Madrid, Ciudad Universitaria, E-28040 Madrid, Spain.
Laboratorio de Difracción de Rayos X de Monocristal, Servicio Interdepartamental de Investigación, Universidad Autónoma de Madrid, E-28049 Madrid, Spain.
Inorg Chem. 2020 Jun 1;59(11):7779-7788. doi: 10.1021/acs.inorgchem.0c00844. Epub 2020 May 15.
The controlled release of functionally active compounds is important in a variety of applications. Here, we have synthesized, characterized, and studied the magnetic properties of three novel metal-metal-bonded tris(formamidinato) Ru complexes. We have used different auxin-related hormones, indole-3-acetate (IAA), 2,4-dichlorophenoxyacetate (2,4-D), and 1-naphthaleneacetate (NAA), to generate [RuCl(μ-DPhF)(μ-IAA)] (), [RuCl(μ-DPhF)(μ-2,4-D)] (), and [RuCl(μ-DPhF)(μ-NAA)] () (DPhF = ,'-diphenylformamidinate). The crystal structures of , , , and have been determined by single-crystal X-ray diffraction. To assess the releasing capacity of the bound hormone, we have employed a biological assay that relied on plants expressing an auxin reporter gene and we demonstrate that the release of the phytohormones from , , and is pH- and time-dependent. These studies serve as a proof of concept showing the potential of these types of compounds as biological molecule carriers.
在各种应用中，功能活性化合物的控制释放是很重要的。在这里，我们合成、表征并研究了三种新型金属-金属键合的三（甲脒基）Ru 配合物的磁性。我们使用了不同的生长素相关激素，吲哚-3-乙酸（IAA）、2,4-二氯苯氧基乙酸（2,4-D）和 1-萘乙酸（NAA），生成 [RuCl(μ-DPhF)(μ-IAA)] (), [RuCl(μ-DPhF)(μ-2,4-D)] (), 和 [RuCl(μ-DPhF)(μ-NAA)] () (DPhF =,'-diphenylformamidinate)。通过单晶 X 射线衍射确定了 、 、 、和 的晶体结构。为了评估结合激素的释放能力，我们采用了一种依赖于表达生长素报告基因的 植物的生物测定法，我们证明了从 、 、和 中释放植物激素是 pH 和时间依赖性的。这些研究证明了这些类型的化合物作为生物分子载体的潜力。
