Modelling the Use of Vaccine and on Dengue Transmission Dynamics.

The use of vaccine and has been proposed as strategies against dengue. Research showed that the intervention is highly effective in areas with low to moderate transmission levels. On the other hand, the use of vaccine is strongly effective when it is implemented on seropositive individuals and areas with high transmission levels. The question that arises is could the combination of both strategies result in higher reduction in the number of dengue cases? This paper seeks to answer the aforementioned question by the use of a mathematical model. A deterministic model in the presence of vaccine and has been developed and analysed. Numerical simulations were presented and public health implications were discussed. The results showed that the performance of in reducing the number of dengue cases is better than that of vaccination if the vaccine efficacy is low, otherwise, the use of vaccine is sufficient to reduce dengue incidence and hence the combination of and vaccine is not necessary.