Department of Pediatric Neurology, Sichuan Provincial Hospital for Women and Children, Chengdu 610045, People's Republic of China.
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, People's Republic of China.
Neurol India. 2020 Mar-Apr;68(2):474-477. doi: 10.4103/0028-3886.283754.
Optic neuritis is an inflammatory demyelinating disorder of the central nervous system. Anti-NMDA receptor (NMDAR) antibodies encephalitis is also mediated by the inappropriate immunological response. We report a girl who was readmitted because of unilateral eye pain and vision impairment in the remission period of anti-NMDAR encephalitis. Based on the limited available literature on the treatment of optic neuritis associated with anti-NMDA receptor antibody, she was treated with a combination of corticosteroids and intravenous immunoglobulin with clinical improvement. Optic neuritis in the remission phase of anti-N-methyl-D-aspartate receptor encephalitis remains relatively uncommon. It is important to document and follow these patients to understand the pathogenesis of optic neuritis in the setting of anti-NMDAR encephalitis and formulate effective therapeutic strategies.
视神经炎是一种中枢神经系统的炎症性脱髓鞘疾病。抗 N-甲基-D-天冬氨酸受体（NMDAR）抗体脑炎也是由不适当的免疫反应介导的。我们报告了一例女孩，她在抗 NMDAR 脑炎缓解期因单侧眼痛和视力下降而再次入院。根据关于抗 NMDAR 抗体相关视神经炎治疗的有限可用文献，她接受了皮质类固醇和静脉注射免疫球蛋白联合治疗，临床症状得到改善。抗 N-甲基-D-天冬氨酸受体脑炎缓解期的视神经炎仍然相对少见。记录和随访这些患者以了解抗 NMDAR 脑炎背景下视神经炎的发病机制并制定有效的治疗策略非常重要。
