铑催化的烯基吡唑中烯基 C-H 键的直接羧化反应。
Rh-Catalyzed Direct Carboxylation of Alkenyl C-H Bonds of Alkenylpyrazoles.
机构信息
Department of Chemistry, Tokyo Institute of Technology, 2-12-1, O-Okayama, Meguro-ku, Tokyo, 152-8551, Japan.
出版信息
Chem Asian J. 2020 Jul 1;15(13):1941-1944. doi: 10.1002/asia.202000476. Epub 2020 Jun 5.
The Rh-catalyzed direct carboxylation of alkenyl C-H bonds was achieved by using pyrazole as a removable directing group. In the presence of 5 mol% RhCl ⋅ 3H O, 6 mol% P(Mes) , and 2 equiv. of AlMe (OMe), the alkenyl C-H bond of various alkenylpyrazoles was directly carboxylated in good yields under CO atmosphere. Furthermore, several useful transformations of the pyrazole moiety of the product were achieved to afford synthetically useful carboxylic acid derivatives in good yields.
通过使用吡唑作为可去除的导向基团，实现了 Rh 催化的烯基 C-H 键的直接羧化反应。在 5 mol% RhCl·3H 2 O、6 mol% P(Mes)和 2 当量 AlMe(OMe)的存在下，在 CO 气氛下，各种烯基吡唑的烯基 C-H 键可以很好地收率直接羧化。此外，还实现了产物中吡唑部分的几种有用转化，以良好的收率得到了合成上有用的羧酸衍生物。
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