Mrsulja B B, Ueki Y, Lust W D
Institute of Biochemistry, School of Medicine, Belgrade, Yugoslavia.
Metab Brain Dis. 1988 Dec;3(4):279-85. doi: 10.1007/BF00999538.
The common carotid arteries were occluded in gerbils for 5 min and the metabolic rate was estimated by measuring the loss of high-energy phosphate equivalents at 4 days of reperfusion in the cerebral cortex, hippocampus, and striatum. Metabolites values at 4 days of reperfusion were not different from those of controls with the exception of glycogen, which was significantly elevated in the hippocampus. The metabolic rate, as determined by the "closed-box" method at 4 days of reflow, was decreased by more than 50% in all three regions after 5 min of bilateral ischemia. The ischemic time necessary to elicit the hypometabolic response at 4 days of reflow was 2, 3 and 4 min for the striatum, hippocampus, and cortex, respectively. It is suggested that delayed postischemic hypometabolism may be a component of an adaptive process which counteracts, to varying degrees, the deleterious effects of ischemia depending on the region examined.
在沙鼠中阻断颈总动脉5分钟，并通过测量再灌注4天时大脑皮层、海马体和纹状体中高能磷酸当量的损失来估计代谢率。再灌注4天时的代谢物值与对照组相比无差异，但糖原除外，糖原在海马体中显著升高。再灌注4天时，通过“封闭箱”法测定的代谢率在双侧缺血5分钟后，所有三个区域均下降超过50%。纹状体、海马体和皮层在再灌注4天时引发代谢减退反应所需的缺血时间分别为2、3和4分钟。提示缺血后延迟性代谢减退可能是一种适应性过程的组成部分，该过程根据所检查的区域不同程度地抵消缺血的有害影响。
