Nicholson G M, Spence I, Johnston G A
Department of Pharmacology, University of Sydney, N.S.W., Australia.
Neurosci Lett. 1988 Nov 11;93(2-3):330-5. doi: 10.1016/0304-3940(88)90104-8.
The actions of convulsant barbiturates were studied on dorsal root ganglion (DRG) cells in vitro using intracellular recording techniques. Only the convulsant barbiturates (+)-DMBB and CHEB produced a concentration-dependent depression in the responses to gamma-aminobutyric acid (GABA). All convulsant barbiturates were found to produce a direct depolarization of the DRG cell membrane which was accompanied by a decrease in the input resistance of the cell and a reduction in the orthodromic action potential. A sub-population of DRG cells were found to be refractory to these actions but there was no relationship between the cell type (A beta, A delta and C) and ability to respond to the convulsant barbiturates.
采用细胞内记录技术，在体外研究了惊厥性巴比妥类药物对背根神经节（DRG）细胞的作用。只有惊厥性巴比妥类药物（+）-DMBB和CHEB对γ-氨基丁酸（GABA）的反应产生浓度依赖性抑制。发现所有惊厥性巴比妥类药物都会使DRG细胞膜直接去极化，同时伴有细胞输入电阻降低和正向动作电位减小。发现一部分DRG细胞对这些作用具有抗性，但细胞类型（Aβ、Aδ和C）与对惊厥性巴比妥类药物的反应能力之间没有关系。
