Arvin B, Neville L F, Roberts P J
Department of Physiology and Pharmacology, University of Southampton, U.K.
Neurosci Lett. 1988 Nov 11;93(2-3):336-40. doi: 10.1016/0304-3940(88)90105-x.
The stable adenosine analogue, 2-chloroadenosine was found to afford a dose-dependent protection (effective dose range: 12.5-50 nmol) against the characteristic neurotoxic actions of kainic acid (2.2 nmol) in rat striatum. The two agents were co-injected directly into the striatum and the extent of the excitotoxin-induced lesion assessed two weeks later in 40 microns coronal sections stained with thionin, or by histochemical staining for NADPH-dependent diaphorase. These findings provide further information concerning the possible mechanism(s) underlying kainic acid-induced neurotoxicity and also yield an insight into a possible neuroprotective role for endogenous adenosine-like substances.
稳定的腺苷类似物2-氯腺苷被发现可对海人酸（2.2纳摩尔）在大鼠纹状体中的特征性神经毒性作用提供剂量依赖性保护（有效剂量范围：12.5 - 50纳摩尔）。将这两种药剂直接共同注射到纹状体中，两周后在经硫堇染色的40微米冠状切片中，或通过对依赖NADPH的黄递酶进行组织化学染色，评估兴奋性毒素诱导损伤的程度。这些发现提供了关于海人酸诱导神经毒性潜在机制的更多信息，也有助于深入了解内源性腺苷样物质可能的神经保护作用。
