帕金森病患者脑脊液中的一种抗体在肾上腺髓质移植后消失。

An antibody in the CSF of Parkinson's disease patients disappears following adrenal medulla transplantation.

作者信息

McRae-Degueurce A, Klawans H L, Penn R D, Dahlstrom A, Tanner C M, Goetz C G, Carvey P M

机构信息

Department of Neurological Sciences, Rush-Presbyterian St. Lukes Medical College, Chicago, IL.

出版信息

Neurosci Lett. 1988 Nov 22;94(1-2):192-7. doi: 10.1016/0304-3940(88)90294-7.

DOI:10.1016/0304-3940(88)90294-7

PMID:3241668

Abstract

CSF from Parkinson's disease (PD) patients undergoing autologous transplantation of adrenal medulla tissue into their lateral ventricle was examined for the presence of IgG. CSF from 6 of 7 patients incubated with rat brain tissue reacted immunocytochemically to neuronal cell bodies in the substantia nigra and ventral tegmental region. This reactivity gradually disappeared in the months following transplantation. Five of 6 CSF samples from non-transplanted PD patients also produced this immunocytochemical reactivity whereas 26 non-PD samples were immunonegative. Possible implications to the transplant procedure are discussed.

摘要

对接受肾上腺髓质组织自体移植入侧脑室的帕金森病（PD）患者的脑脊液进行检测，以确定是否存在IgG。7例患者中有6例的脑脊液与大鼠脑组织孵育后，在黑质和腹侧被盖区的神经元细胞体上产生免疫细胞化学反应。这种反应性在移植后的几个月内逐渐消失。6例未移植的PD患者的脑脊液样本中有5例也产生了这种免疫细胞化学反应，而26例非PD样本呈免疫阴性。文中讨论了该检测结果对移植手术可能的影响。