Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan.
Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan; Chang Gung University, College of Medicine, Taoyuan, Taiwan.
J Formos Med Assoc. 2021 Jan;120(1 Pt 1):250-255. doi: 10.1016/j.jfma.2020.04.032. Epub 2020 May 14.
To better understand population-specific tumor characteristics and behavior of conjunctival melanoma in Asian.
A retrospective cohort enrolled patients with primary conjunctival melanoma treated and followed up at Chang Gung Memorial Hospital (CGMH) in Taiwan between 1995 and 2015. Basic characteristics such as age, gender, tumor size, cell type, location, and TNM stage were recorded. Prognostic parameters included disease free interval, local recurrence, distant metastasis, and survival were analyzed.
There were 20 patients enrolled in the study hospital between 1995 and 2015. All were histological proved by pathologists. Their mean age at diagnosis was 57.8 ± 15.9 years. The mean follow-up time was 68.7 ± 55.8 months. Mean tumor thickness was 6.5 ± 5.9 mm. Six patients developed local recurrence. Twelve patients had distant metastasis. Ten patients died from conjunctival melanoma. The 10 patients had greater mean tumor thickness (8.4 ± 7.5 mm) and shorter mean survival time (40.2 ± 24.1 months). Tumor thickness was found as a prognostic factor for survival time (HR = 1.15, P = 0.01). Age, gender, T stage, and tumor location were not significantly associated with survival.
Different tumor characteristics were found in this cohort. Higher metastasis and mortality rate could suggest a more aggressive disease pattern. Tumor thickness was indicated as a prognostic factor for survival time and was greater in size in cases with distant metastasis. Early and more invasive intervention with closely follow-up may be indicated in these cases.
为了更好地了解亚洲人群中结膜黑色素瘤的特定肿瘤特征和行为。
回顾性队列研究纳入了 1995 年至 2015 年在台湾长庚纪念医院治疗和随访的原发性结膜黑色素瘤患者。记录了患者的基本特征，如年龄、性别、肿瘤大小、细胞类型、位置和 TNM 分期。分析了无病间隔、局部复发、远处转移和生存等预后参数。
该研究医院共纳入 20 例患者，均经病理学家证实为组织学。他们的诊断时平均年龄为 57.8±15.9 岁。平均随访时间为 68.7±55.8 个月。平均肿瘤厚度为 6.5±5.9mm。6 例患者发生局部复发，12 例患者发生远处转移，10 例患者死于结膜黑色素瘤。10 例患者的肿瘤厚度较大（8.4±7.5mm），生存时间较短（40.2±24.1 个月）。肿瘤厚度被发现是生存时间的预后因素（HR=1.15，P=0.01）。年龄、性别、T 分期和肿瘤位置与生存无显著相关性。
本队列中发现了不同的肿瘤特征。较高的转移率和死亡率可能表明疾病更具侵袭性。肿瘤厚度是生存时间的预后因素，在远处转移的病例中更大。早期、更具侵袭性的干预措施并密切随访可能适用于这些病例。
