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HLA-A∗68, -A∗11:01, and -A∗29:02 alleles are strongly associated with benznidazole-induced maculopapular exanthema (MPE)/DRESS.

作者信息

Balas Antonio, Ramírez Elena, Trigo Elena, Cabañas Rosario, Fiandor Ana, Arsuaga Marta, Lerma Victoria, Sanz Beatriz, LuisVicario José, Herranz Pedro, de Abajo Francisco, Bellón Teresa

机构信息

Histocompatibility, Centro de Transfusión de Madrid, Madrid, Spain.

Clinical Pharmacology Department, Hospital Universitario La Paz-Carlos III-Cantoblanco, IdiPAZ, School of Medicine, Autonomous University of Madrid, Madrid, Spain.

出版信息

J Allergy Clin Immunol Pract. 2020 Oct;8(9):3198-3200.e3. doi: 10.1016/j.jaip.2020.05.004. Epub 2020 May 14.

DOI:10.1016/j.jaip.2020.05.004
PMID:32417447
Abstract
摘要

相似文献

1
HLA-A∗68, -A∗11:01, and -A∗29:02 alleles are strongly associated with benznidazole-induced maculopapular exanthema (MPE)/DRESS.HLA - A∗68、-A∗11:01和-A∗29:02等位基因与苄硝唑诱导的斑丘疹性皮疹(MPE)/药物超敏反应伴嗜酸性粒细胞增多和系统症状(DRESS)密切相关。
J Allergy Clin Immunol Pract. 2020 Oct;8(9):3198-3200.e3. doi: 10.1016/j.jaip.2020.05.004. Epub 2020 May 14.
2
Genotype-phenotype association between HLA and carbamazepine-induced hypersensitivity reactions: strength and clinical correlations.HLA 与卡马西平诱导的过敏反应的基因型-表型关联:强度和临床相关性。
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Comparative histological analysis of drug-induced maculopapular exanthema and DRESS.药物性斑丘疹性皮疹和药物超敏反应伴嗜酸性粒细胞增多和系统症状的比较组织学分析。
J Eur Acad Dermatol Venereol. 2016 Dec;30(12):2085-2090. doi: 10.1111/jdv.13832. Epub 2016 Jul 16.
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HLA-associated antiepileptic drug-induced cutaneous adverse reactions.HLA 相关的抗癫痫药诱导的皮肤不良反应。
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Cutaneous drug reactions to antiepileptic drugs and relation with HLA alleles in the Turkish population.土耳其人群中抗癫痫药物的皮肤药物反应及其与HLA等位基因的关系。
Eur Ann Allergy Clin Immunol. 2018 Jan;50(1):36-41. doi: 10.23822/EurAnnACI.1764-1489.23.
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Association between HLA-B Alleles and Carbamazepine-Induced Maculopapular Exanthema and Severe Cutaneous Reactions in Thai Patients.泰国患者 HLA-B 等位基因与卡马西平诱导的斑丘疹和严重皮肤反应的关联。
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Association of cutaneous adverse drug reactions due to antiepileptic drugs with HLA alleles in a North Indian population.在印度北部人群中,与抗癫痫药物相关的皮肤不良反应与 HLA 等位基因有关。
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Overlap between maculopapular exanthema and drug reaction with eosinophilia and systemic symptoms among cutaneous adverse drug reactions in a dermatology ward.皮肤科病房中药物不良反应的斑丘疹样发疹与药物反应伴嗜酸性粒细胞增多和全身症状之间存在重叠。
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Recommendations for HLA-B*15:02 and HLA-A*31:01 genetic testing to reduce the risk of carbamazepine-induced hypersensitivity reactions.建议进行 HLA-B*15:02 和 HLA-A*31:01 基因检测,以降低卡马西平诱导的过敏反应风险。
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引用本文的文献

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Advances in understanding of the pathogenesis and therapeutic implications of drug reaction with eosinophilia and systemic symptoms: an updated review.药物超敏反应伴嗜酸性粒细胞增多和全身症状的发病机制及治疗意义的研究进展:最新综述
Front Med (Lausanne). 2023 Jun 29;10:1187937. doi: 10.3389/fmed.2023.1187937. eCollection 2023.
2
LTT and HLA testing as diagnostic tools in Spanish vancomycin-induced DRESS cases: A case-control study.淋巴细胞毒试验(LTT)和人类白细胞抗原(HLA)检测作为西班牙万古霉素诱导的药物超敏反应伴嗜酸性粒细胞增多和系统症状(DRESS)病例的诊断工具:一项病例对照研究
Front Pharmacol. 2022 Oct 20;13:959321. doi: 10.3389/fphar.2022.959321. eCollection 2022.
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Mixed T Helper1/T Helper2/T Cytotoxic Profile in Subjects with Chronic Chagas Disease with Hypersensitivity Reactions to Benznidazole.
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Genomic Risk Factors Driving Immune-Mediated Delayed Drug Hypersensitivity Reactions.驱动免疫介导的迟发性药物超敏反应的基因组风险因素。
Front Genet. 2021 Apr 16;12:641905. doi: 10.3389/fgene.2021.641905. eCollection 2021.