Koleva M, Kuneva T, Boiadzhieva P
Probl Khig. 1988;13:124-9.
During a 3-month experiment is studied the effect of enriched with iron, calcium, phosphorous and vitamin D2 food ration on the changes in the organospecific enzymes in everyday introduction in the organism of experimental animals of cadmium sulfate in dose 1/40 LD50 (7 mg/kg-1). The serum activity of GOT and GPT is traced in dynamics at the end of the first, second and third month, as well as the activity of gamma-GT, LAP and APh in homogenates of liver and kidneys. The changes established in most of the experimental groups and the dates of observation show an increase in the serum and tissue activity of the examined enzymes (GOT, GPT, LAP). The tissue activity of gamma-GT and the quantity of free sulfhydryl groups are decreased in some of the dates of observation (I and III month). Both the isolated effect of cadmium and enriched food ration and their combined effect are discussed.
在为期3个月的实验中，研究了富含铁、钙、磷和维生素D2的食物日粮对以1/40 LD50（7毫克/千克-1）剂量每日给实验动物机体注射硫酸镉后器官特异性酶变化的影响。在第1、2和3个月末动态追踪血清中谷草转氨酶（GOT）和谷丙转氨酶（GPT）的活性，以及肝脏和肾脏匀浆中γ-谷氨酰转肽酶（gamma-GT）、亮氨酸氨基肽酶（LAP）和碱性磷酸酶（APh）的活性。在大多数实验组中观察到的变化以及观察日期表明，所检测酶（GOT、GPT、LAP）的血清和组织活性增加。在某些观察日期（第1和第3个月），γ-谷氨酰转肽酶的组织活性和游离巯基数量减少。文中讨论了镉的单独作用、富含营养的食物日粮以及它们的联合作用。
