Peschke D, Wetzig H, Fengler F
Gegenbaurs Morphol Jahrb. 1981;127(6):763-71.
Male young and adult Wistar-rats were used to investigate the heavy metal pattern of the liver after application of CdCl2 (dosage: 50 ppm or 150 ppm) solved in the drinking-water. The duration of the experiment was 1, 3, 6, or 12 month. Under these conditions, an increasing accumulation of heavy metal storages in the liver was obtained. The most conspicuous structure of the normal heavy metal pattern is a fine network of heavy metal storages accompanying the bile capillaries. The stellate cells (Kupffer) react positive too. Under cadmium poisoning mainly quantitative changes of this ground pattern was obtained. Additional small little storages may be scattered in the nuclei and in other regions of the liver cells. There are storages in the epithelium of small bile ducts and in the inner and the middle layer of blood vessels too. The increase of storages was medium in the first 3 month of the experiment. Fast storages were obtained after 6 and 12 month.
雄性幼年和成年Wistar大鼠被用于研究饮用含有溶解的CdCl2（剂量：50 ppm或150 ppm）的水后肝脏中的重金属模式。实验持续时间为1、3、6或12个月。在这些条件下，肝脏中重金属储存量不断增加。正常重金属模式最明显的结构是伴随胆小管的重金属储存细网络。星状细胞（库普弗细胞）也呈阳性反应。在镉中毒情况下，主要获得了这种基本模式的定量变化。额外的小储存可能分散在细胞核和肝细胞的其他区域。小胆管上皮以及血管的内层和中层也有储存。实验前3个月储存量增加适中。6个月和12个月后储存量快速增加。
