迟发性运动障碍与假性帕金森症的关联。

The association of tardive dyskinesia and pseudoparkinsonism.

Yassa R, Nair V

Douglas Hospital Research Centre, Department of Psychiatry, McGill University, Montreal, Quebec.

Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(6):909-14. doi: 10.1016/0278-5846(88)90087-5.

Abstract

A survey of 315 chronic inpatients for the presence of extrapyramidal side effects indicates that 58.7% of the patients had no evidence of extrapyramidal side effects, 28.6% had tardive dyskinesia (TD) alone, 8.9% had pseudoparkinsonism and 3.8% had a combination of both. 2. Women seemed to exhibit more side effects. 3. Aging was another factor associated with a higher risk for the appearance of extrapyramidal side effects. 4. Affective disorder patients carried more risk than patients with schizophrenia. 5. The low prevalence of the combined TD and pseudoparkinsonism may be related to several factors. The possible explanations are explored and discussed. These patients present a therapeutic dilemma.

摘要

一项针对315名慢性住院患者锥体外系副作用情况的调查表明，58.7%的患者没有锥体外系副作用的迹象，28.6%的患者仅患有迟发性运动障碍（TD），8.9%的患者患有假性帕金森症，3.8%的患者同时患有这两种病症。2. 女性似乎表现出更多的副作用。3. 年龄增长是另一个与锥体外系副作用出现风险较高相关的因素。4. 情感障碍患者比精神分裂症患者面临更多风险。5. TD和假性帕金森症合并症的低患病率可能与几个因素有关。对可能的解释进行了探讨和讨论。这些患者面临着治疗困境。