Pandurangi A K, Aderibigbe Y A
Department of Psychiatry, Medical College of Virginia, Richmond 23298-0710, USA.
Eur Arch Psychiatry Clin Neurosci. 1995;246(1):47-52. doi: 10.1007/BF02191814.
Tardive dyskinesia (TD) is a well-described adverse effect of treatment with neuroleptics. Studies from non-western countries are sparse and those that exist are not well publicized. We analyzed prevalence data on TD, published in English or French, and carried out in countries in Africa and Asia through December 1993. The estimated prevalence of TD among African subjects was 24% and among Asian subjects 17.2091. Both rates are in the middle range when compared with the western prevalence rates of 10-50%. Long-term hospitalization and older age were risk factors associated with TD. Female gender did not emerge as a risk factor. Also, several Asian studies showed that subjects with TD were taking lower doses of neuroleptics than subjects without TD. Prospective and controlled cross-cultural studies of TD are recommended for better understanding of associated risk factors and primary prevention.
迟发性运动障碍（TD）是一种已被充分描述的抗精神病药物治疗的不良反应。来自非西方国家的研究较少，且已有的研究并未得到广泛宣传。我们分析了截至1993年12月在非洲和亚洲国家开展并以英文或法文发表的关于TD的患病率数据。非洲受试者中TD的估计患病率为24%，亚洲受试者为17.2091%。与西方10%-50%的患病率相比，这两个比率均处于中等范围。长期住院和高龄是与TD相关的危险因素。女性并未表现为危险因素。此外，一些亚洲研究表明，患有TD的受试者服用的抗精神病药物剂量低于未患TD的受试者。建议开展TD的前瞻性对照跨文化研究，以更好地了解相关危险因素和一级预防。
