Federal University of Sao Paulo, Diadema, SP, Brazil.
Federal University of Sao Paulo, Diadema, SP, Brazil.
Chem Phys Lipids. 2020 Aug;230:104915. doi: 10.1016/j.chemphyslip.2020.104915. Epub 2020 May 11.
The compound γ-terpineol, which presents potential as microbicide and anticancer drug, was incorporated in cholesterol Langmuir monolayers, pure or mixed with DPPC. The compound expands the monolayers at higher molecular areas, but condenses them at lower areas, indicating a structural molecular rearrangement of γ-terpineol at the-water interface upon compression. Such effect was confirmed with rheological, surface potential, Brewster angle microscopy and infrared data, which indicated, respectively, reduction of the compressional modulus of the lipid monolayer, decrease of the surface potential, formation of aggregates, and alteration of the trans/gauche conformers ratio for methylene groups. Distinctive effects were observed for cholesterol monolayers without or with the presence of DPPC. Such results may help understand how the interaction of γ-terpineol with lipidic surfaces is modulated by lipids able to mediate the packing state of biointerfaces.
具有杀微生物剂和抗癌药物潜力的化合物γ-松油醇被掺入胆固醇 Langmuir 单层中，无论是纯的还是与 DPPC 混合的。该化合物在较高的分子区域扩张单层，但在较低的区域使它们凝聚，表明γ-松油醇在压缩时在水界面处的结构分子重排。流变学、表面电势、布鲁斯特角显微镜和红外数据证实了这种效应，分别表示脂质单层的压缩模量降低、表面电势降低、形成聚集体以及亚甲基的顺/反式构象比例改变。在没有或存在 DPPC 的情况下，胆固醇单层表现出明显不同的效果。这些结果可能有助于理解γ-松油醇与脂质表面的相互作用如何被能够调节生物界面的包装状态的脂质调节。
