Rhein Cosima, Mühle Christiane, Lenz Bernd, Richter-Schmidinger Tanja, Kogias Georgios, Boix Fernando, Lourdusamy Anbarasu, Dörfler Arnd, Peters Oliver, Ramirez Alfredo, Jessen Frank, Maier Wolfgang, Hüll Michael, Frölich Lutz, Teipel Stefan, Wiltfang Jens, Kornhuber Johannes, Müller Christian P
Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander University Erlangen-Nürnberg, Schwabachanlage 6, 91054 Erlangen, Germany.
Department of Psychiatry and Psychotherapy, University Clinic, Friedrich-Alexander University Erlangen-Nürnberg, Schwabachanlage 6, 91054 Erlangen, Germany; Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health (CIMH), Medical Faculty Mannheim, Heidelberg University, Germany.
Brain Res Bull. 2020 Aug;161:13-20. doi: 10.1016/j.brainresbull.2020.05.001. Epub 2020 May 11.
Calcium/Calmodulin-dependent kinase alpha (αCaMKII) has been shown to play an essential role in synaptic plasticity and in learning and memory in animal models. However, there is little evidence for an involvement in specific memories in humans. Here we tested the potential involvement of the αCaMKII coding gene CAMK2A in verbal logical memory in two Caucasian populations from Germany, in a sample of 209 elderly people with cognitive impairments and a sample of 142 healthy adults. The association of single nucleotide polymorphisms (SNPs) located within the genomic region of CAMK2A with verbal logical memory learning and retrieval from the Wechsler Memory Scale was measured and hippocampal volume was assessed by structural MRI. In the elderly people, we found the minor allele of CAMK2A intronic SNP rs919741 to predict a higher hippocampal volume and better logical memory retrieval. This association was not found in healthy adults. The present study may provide evidence for an association of a genetic variant of the CAMK2A gene specifically with retrieval of logical memory in elderly humans. This effect is possibly mediated by a higher hippocampal volume.
钙/钙调蛋白依赖性激酶α（αCaMKII）已被证明在动物模型的突触可塑性以及学习和记忆中发挥着至关重要的作用。然而，几乎没有证据表明其参与人类的特定记忆。在此，我们在来自德国的两个白种人群体中，对209名有认知障碍的老年人样本和142名健康成年人样本，测试了αCaMKII编码基因CAMK2A在言语逻辑记忆中的潜在作用。测量了位于CAMK2A基因区域内的单核苷酸多态性（SNP）与韦氏记忆量表中的言语逻辑记忆学习和提取之间的关联，并通过结构磁共振成像评估了海马体积。在老年人中，我们发现CAMK2A内含子SNP rs919741的次要等位基因可预测更高的海马体积和更好的逻辑记忆提取。在健康成年人中未发现这种关联。本研究可能为CAMK2A基因的一个遗传变异与老年人类逻辑记忆的提取之间的关联提供了证据。这种效应可能由更大的海马体积介导。
