男性尿道狭窄疾病治疗的最新进展
Recent Advances in treatment of urethral stricture disease in men.
作者信息
Mangir Naside, Chapple Christopher
机构信息
Department of Functional and Reconstructive Urology, Royal Hallamshire Hospital, Glossop Road, Sheffield, S10 2JF, UK.
出版信息
F1000Res. 2020 May 5;9. doi: 10.12688/f1000research.21957.1. eCollection 2020.
Abstract
Urethral stricturing is a narrowing of the urethral lumen as a result of ischaemic spongiofibrosis. The main challenge of currently available treatment options is recurrence of the stricture. Recent advancements in the treatment of urethral strictures mainly came from the fields of regenerative medicine and tissue engineering. Research efforts have primarily focused on decreasing the recurrence of stricture after internal urethrotomy and constructing tissue-engineered urethral substitutes to improve clinical outcomes of urethroplasty surgeries. The aim of this article is to review the most recent advancements in the management of urethral stricture disease in men.
摘要
尿道狭窄是由于缺血性海绵体纤维化导致尿道腔狭窄。目前可用治疗方案的主要挑战是狭窄复发。尿道狭窄治疗的最新进展主要来自再生医学和组织工程领域。研究工作主要集中在减少内切开术后狭窄的复发以及构建组织工程尿道替代物以改善尿道成形术的临床效果。本文旨在综述男性尿道狭窄疾病治疗的最新进展。
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本文引用的文献
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A drug-coated balloon treatment for urethral stricture disease: Interim results from the ROBUST I study.一种用于尿道狭窄疾病的药物涂层球囊治疗：ROBUST I研究的中期结果。
Can Urol Assoc J. 2020 Jun;14(6):187-191. doi: 10.5489/cuaj.6323.
2
Liquid buccal mucosa graft endoscopic urethroplasty: a validation animal study.经尿道内镜下液体颊黏膜移植术：一种验证性动物研究。
World J Urol. 2020 Sep;38(9):2139-2145. doi: 10.1007/s00345-019-02840-5. Epub 2019 Jun 7.
3
TNF-α-induced exosomal miR-146a mediates mesenchymal stem cell-dependent suppression of urethral stricture.TNF-α 诱导的细胞外体 miR-146a 介导间充质干细胞依赖性抑制尿道狭窄。
J Cell Physiol. 2019 Dec;234(12):23243-23255. doi: 10.1002/jcp.28891. Epub 2019 May 29.
4
Current state of urethral tissue engineering.尿道组织工程的现状
Curr Opin Urol. 2019 Jul;29(4):385-393. doi: 10.1097/MOU.0000000000000637.
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The effect of platelet-rich plasma injection on post-internal urethrotomy stricture recurrence.富血小板血浆注射对尿道内切开术后狭窄复发的影响。
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Int J Urol. 2019 Feb;26(2):253-257. doi: 10.1111/iju.13852. Epub 2018 Nov 22.
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9
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J Thromb Haemost. 2018 Sep;16(9):1895-1900. doi: 10.1111/jth.14223. Epub 2018 Aug 11.
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J Endourol. 2018 May;32(5):381-386. doi: 10.1089/end.2017.0935. Epub 2018 Mar 2.
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