微小RNA在胃肠道恶性肿瘤易感性中的作用。
Role of microRNAs in the predisposition to gastrointestinal malignancies.
作者信息
Baz Maria, Ibrahim Tony
机构信息
Department of Tumor Molecular Biology, Gustave Roussy Cancer Campus, Villfejuif 94805, France.
Department of Medical Oncology, Gustave Roussy Cancer Campus, Villfejuif 94805, France.
出版信息
World J Clin Cases. 2020 May 6;8(9):1580-1585. doi: 10.12998/wjcc.v8.i9.1580.
Abstract
MicroRNAs (miRNAs) are highly deregulated in cancer and play a role in the initiation of tumorigenesis. Recently, miRNAs have attracted attention in gastrointestinal (GI) cancers. Single nucleotide polymorphisms (SNPs) could affect the genes involved in each step of miRNA biosynthesis. Several meta-analyses of case-control studies have assessed the association between miRNA "pathway" gene-SNPs (including biosynthesis regulators and binding sites) and susceptibility to GI cancers. We present in this mini-review the current knowledge on the association between miRNAs "pathway" genes and GI cancer predisposition. The interaction between miRNA/regulators/binding site-SNPs and environmental as well as genomic factors is an interesting field that should be exploited in future studies.
摘要
微小RNA（miRNA）在癌症中高度失调，并在肿瘤发生起始过程中发挥作用。最近，miRNA在胃肠道（GI）癌症中引起了关注。单核苷酸多态性（SNP）可能影响miRNA生物合成各个步骤中涉及的基因。多项病例对照研究的荟萃分析评估了miRNA“通路”基因SNP（包括生物合成调节因子和结合位点）与GI癌症易感性之间的关联。在本综述中，我们介绍了关于miRNA“通路”基因与GI癌症易感性之间关联的当前知识。miRNA/调节因子/结合位点SNP与环境以及基因组因素之间的相互作用是一个有趣的领域，应在未来研究中加以探索。
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