Student Research Committee, Qazvin University of Medical Sciences, School of Medicine, Qazvin, Iran.
Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran; Medical Biotechnology Department, Faculty of Paramedical Sciences, Qazvin University of Medical Sciences, Qazvin, Iran.
Crit Rev Eukaryot Gene Expr. 2020;30(1):1-18. doi: 10.1615/CritRevEukaryotGeneExpr.2019025774.
The Wnt signaling pathway appears to activate intracellular signaling transduction in embryonic development, cell migration, hematopoiesis, and several diseases. Wnt signaling is basically recognized as a canonical β-catenin-dependent signaling pathway. However, in recent years, generally three Wnt-mediated pathways have been investigated, which operate independently of β-catenin and include calcium/calmodulin-dependent kinase II and protein kinase C, planar cell polarity, and a third one recruits hetrotrimeric GTP-binding proteins to stimulate phospholipase C and phosphodiesterase. We provide an overview of the noncanonical Wnt signaling pathway and then will focus on canonical Wnt signaling components, Wnt ligands, agonists, and antagonist. This review will also discuss β-catenin, both cytoplasmic and nuclear mechanisms, through signaling transduction, and, as a consequence, we have briefly highlighted potential implications of Wnt/β-catenin in some cancers.
Wnt 信号通路似乎在胚胎发育、细胞迁移、造血和多种疾病中激活细胞内信号转导。Wnt 信号被基本认为是一种经典的β-连环蛋白依赖性信号通路。然而，近年来，人们普遍研究了三种由 Wnt 介导的途径，它们独立于β-连环蛋白发挥作用，包括钙/钙调蛋白依赖性激酶 II 和蛋白激酶 C、平面细胞极性，以及第三种途径招募异三聚体 GTP 结合蛋白来刺激磷脂酶 C 和磷酸二酯酶。我们概述了非经典的 Wnt 信号通路，然后将重点介绍经典的 Wnt 信号成分、Wnt 配体、激动剂和拮抗剂。本综述还将讨论β-连环蛋白，包括细胞质和核机制，通过信号转导，因此，我们简要强调了 Wnt/β-连环蛋白在某些癌症中的潜在意义。
