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扩大边缘供者肝移植的供者池。

Expanding the donor pool for liver transplantation with marginal donors.

机构信息

Department of Surgery, Division of Transplant Surgery, University of Virginia, Charlottesville, VA, USA.

Division of HBP Surgery & Liver Transplantation, Department of Surgery, Korea University College of Medicine, Seoul, South Korea.

出版信息

Int J Surg. 2020 Oct;82S:30-35. doi: 10.1016/j.ijsu.2020.05.024. Epub 2020 May 15.

DOI:10.1016/j.ijsu.2020.05.024
PMID:32422385
Abstract

The current supply of acceptable donor livers is not sufficient to meet the demands of listed patients awaiting transplantation resulting in thousands of deaths each year. Increased utilization of marginal livers may help alleviate this supply/demand mismatch by expanding the donor liver pool. The current status of liver transplantation using marginal donor grafts and efforts to optimize usage are discussed with attention to elderly donors, steatotic livers, donors after circulatory death, and split liver grafts.

摘要

目前可接受的供体肝脏供应不足以满足等待移植的患者的需求,导致每年都有数千人死亡。增加边缘供肝的利用率可以通过扩大供肝池来帮助缓解这种供需不匹配的情况。本文讨论了使用边缘供体移植物进行肝移植的现状以及优化使用的努力,特别关注老年供体、脂肪肝、循环死亡后供体和劈裂肝移植。

相似文献

1
Expanding the donor pool for liver transplantation with marginal donors.扩大边缘供者肝移植的供者池。
Int J Surg. 2020 Oct;82S:30-35. doi: 10.1016/j.ijsu.2020.05.024. Epub 2020 May 15.
2
Donation after circulatory death liver transplantation: What are the limits for an acceptable DCD graft?循环死亡器官捐献肝移植:什么样的 DCD 移植物是可接受的?
Int J Surg. 2020 Oct;82S:36-43. doi: 10.1016/j.ijsu.2020.04.064. Epub 2020 May 7.
3
Liver transplantation: expanding the donor and recipient pool.肝移植:扩大供体和受体池。
Chin Clin Oncol. 2021 Feb;10(1):6. doi: 10.21037/cco-20-212. Epub 2020 Dec 14.
4
Expanding the donor pool for liver transplantation.扩大肝移植的供体库。
Curr Gastroenterol Rep. 2000 Feb;2(1):46-54. doi: 10.1007/s11894-000-0051-7.
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Role of basic studies in expanding the donor pool for liver transplantation.基础研究在扩大肝移植供体库中的作用。
Hepatobiliary Pancreat Dis Int. 2008 Dec;7(6):571-80.
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Expanding the donor pool: use of marginal donors for solid organ transplantation.扩大供体库:边缘供体在实体器官移植中的应用。
Clin Transplant. 1996 Feb;10(1 Pt 1):1-19.
7
Birmingham liver unit: use of marginal donors for liver transplantation.伯明翰肝脏中心:边缘供体在肝移植中的应用
Clin Transpl. 2008:137-42.
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The use of marginal grafts in liver transplantation.边缘供肝在肝移植中的应用。
J Hepatobiliary Pancreat Surg. 2008;15(2):92-101. doi: 10.1007/s00534-007-1300-z. Epub 2008 Apr 6.
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Expanding the donor pool for liver transplantation in the setting of an "opt-out" scheme: 3 years after new legislation.在“选择退出”计划背景下扩大肝移植供体库:新立法三年后
Ann Acad Med Singap. 2009 Apr;38(4):315-7.
10
Current status of liver transplantation in North America.北美地区肝移植的现状。
Int J Surg. 2020 Oct;82S:9-13. doi: 10.1016/j.ijsu.2020.05.059. Epub 2020 May 28.

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Longitudinal Assessment of Performance Status in US Liver Transplantation: National Trends and Survival Implications.美国肝移植中功能状态的纵向评估:全国趋势及生存影响
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Prolonged allograft survival in liver transplantation.
肝移植中同种异体移植物的长期存活
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Elderly Ages in Liver Transplantation: Are Older Donors Really Higher Risk?肝移植中的老年受者:老年供者风险真的更高吗?
Transplant Direct. 2025 Apr 9;11(5):e1789. doi: 10.1097/TXD.0000000000001789. eCollection 2025 May.
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Insulin-induced gene 2 alleviates ischemia-reperfusion injury in steatotic liver by inhibiting GPX4-dependent ferroptosis.胰岛素诱导基因2通过抑制GPX4依赖性铁死亡减轻脂肪变性肝脏的缺血再灌注损伤。
Cell Death Discov. 2025 Apr 1;11(1):127. doi: 10.1038/s41420-025-02406-y.
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Analysis of Unused Organ Donors in the Netherlands: Older Donor Age Associated With Higher Risk of Non-Utilization.荷兰未使用器官捐赠者分析:捐赠者年龄较大与未被利用的风险较高相关。
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Molecular Mechanisms of Ischemia/Reperfusion Injury and Graft Dysfunction in Liver Transplantation: Insights from Multi-Omics Studies in Rodent Animal Models.肝移植中缺血/再灌注损伤及移植物功能障碍的分子机制:来自啮齿动物模型多组学研究的见解
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Shortening the recipient warm ischemia time could be a strategy for expanding the liver donor pool.缩短受者热缺血时间可能是扩大肝脏供体库的一种策略。
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Perspectives and Tools in Liver Graft Assessment: A Transformative Era in Liver Transplantation.肝脏移植评估的视角与工具:肝脏移植的变革时代
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