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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Hodek P, Janscák P, Anzenbacher P, Burkhard J, Janků J, Vodicka L

Department of Biochemistry, Charles University, Czechoslovakia.

Xenobiotica. 1988 Oct;18(10):1109-18. doi: 10.3109/00498258809042233.

Diamantane binds to liver microsomes from phenobarbital-treated rats with an apparent Ks value of 5.2 x 10(-7) mol/l. This value being lower than that obtained for perhydrophenanthrene indicates that diamantane is very strongly bound to microsomal cytochrome P-450. 2. Metabolic studies show that liver microsomes from phenobarbital-treated rats readily metabolize diamantane to mono-, di- and possibly tri-hydroxy derivatives, whereas liver microsomes from beta-naphthoflavone-induced rats do not bind this hydrocarbon or metabolize it. 3. Reconstituted cytochromes P-450 b and e were more efficient in the hydroxylation of diamantane than liver microsomes; metabolites formed by the reconstituted system do not include all the products formed by microsomes, which indicates the involvement of forms of cytochrome P-450 other than the isozymes b and e.

金刚烷与经苯巴比妥处理的大鼠肝脏微粒体结合，其表观Ks值为5.2×10⁻⁷mol/L。该值低于全氢菲的相应值，表明金刚烷与微粒体细胞色素P - 450结合非常紧密。2. 代谢研究表明，经苯巴比妥处理的大鼠肝脏微粒体可轻易将金刚烷代谢为单羟基、二羟基以及可能的三羟基衍生物，而经β - 萘黄酮诱导的大鼠肝脏微粒体既不结合该烃类也不代谢它。3. 重组细胞色素P - 450 b和e在金刚烷的羟基化反应中比肝脏微粒体更有效；重组系统形成的代谢产物并不包括微粒体形成的所有产物，这表明除了同功酶b和e之外，细胞色素P - 450的其他形式也参与其中。

Hodek P, Janscák P, Anzenbacher P, Burkhard J, Janků J, Vodicka L

Department of Biochemistry, Charles University, Czechoslovakia.

Xenobiotica. 1988 Oct;18(10):1109-18. doi: 10.3109/00498258809042233.

Diamantane binds to liver microsomes from phenobarbital-treated rats with an apparent Ks value of 5.2 x 10(-7) mol/l. This value being lower than that obtained for perhydrophenanthrene indicates that diamantane is very strongly bound to microsomal cytochrome P-450. 2. Metabolic studies show that liver microsomes from phenobarbital-treated rats readily metabolize diamantane to mono-, di- and possibly tri-hydroxy derivatives, whereas liver microsomes from beta-naphthoflavone-induced rats do not bind this hydrocarbon or metabolize it. 3. Reconstituted cytochromes P-450 b and e were more efficient in the hydroxylation of diamantane than liver microsomes; metabolites formed by the reconstituted system do not include all the products formed by microsomes, which indicates the involvement of forms of cytochrome P-450 other than the isozymes b and e.

金刚烷与经苯巴比妥处理的大鼠肝脏微粒体结合，其表观Ks值为5.2×10⁻⁷mol/L。该值低于全氢菲的相应值，表明金刚烷与微粒体细胞色素P - 450结合非常紧密。2. 代谢研究表明，经苯巴比妥处理的大鼠肝脏微粒体可轻易将金刚烷代谢为单羟基、二羟基以及可能的三羟基衍生物，而经β - 萘黄酮诱导的大鼠肝脏微粒体既不结合该烃类也不代谢它。3. 重组细胞色素P - 450 b和e在金刚烷的羟基化反应中比肝脏微粒体更有效；重组系统形成的代谢产物并不包括微粒体形成的所有产物，这表明除了同功酶b和e之外，细胞色素P - 450的其他形式也参与其中。