Department of Radiology, Renmin Hospital of 12390Wuhan University, Wuhan, PR China.
Acta Radiol. 2021 Feb;62(2):251-259. doi: 10.1177/0284185120923270. Epub 2020 May 18.
Patients with alcohol-use disorder (AUD) demonstrate dysfunctional cerebral network connectivity. However, limited studies have investigated attention systems in AUD.
To assess functional (FC) and effective connectivity (EC) in the dorsal (DAN) and ventral attention networks (VAN) and default mode network (DMN) in patients with AUD using resting-state functional magnetic resonance imaging (rs-fMRI).
MRI and rs-fMRI data were obtained from 28 men with AUD and 30 age-matched healthy controls. Independent component analysis was used to identify and extract network data, for comparison between the two groups. Effective connectivity was evaluated using Granger causality analysis (GCA) by selecting significantly different brain areas as regions of interest (ROI). Signed-path coefficients between ROIs were computed in bivariate mode.
In patients with AUD, FC decreased in the left superior parietal gurus (SPG) and left interparietal sulcus (IPS, in DAN); FC decreased in the right superior frontal gyrus (SPG) and right middle frontal gyrus (MFG, in DMN). GCA values indicated that the DMN exerts a positive causal effect on the DAN ( = 0.007/0.027), which consequently exerts a negative causal effect on the DMN ( = 0.032). Signed-path coefficients from the right MFG to the left IPS correlated negatively with MAST scores ( = 0.015).
We found novel inter-network connectivity dysfunction in patients with AUD, which indicates abnormal causal relations between resting-state DAN and DMN. Thus, patients with AUD may have abnormal top-down attention modulation and cognition.
患有酒精使用障碍（AUD）的患者表现出大脑网络连接功能障碍。然而，有限的研究调查了 AUD 中的注意系统。
使用静息态功能磁共振成像（rs-fMRI）评估 AUD 患者背侧（DAN）和腹侧注意网络（VAN）以及默认模式网络（DMN）的功能（FC）和有效连接（EC）。
对 28 名男性 AUD 患者和 30 名年龄匹配的健康对照者进行 MRI 和 rs-fMRI 数据采集。使用独立成分分析（ICA）来识别和提取网络数据，以比较两组之间的差异。通过选择显著不同的脑区作为感兴趣区（ROI），使用格兰杰因果分析（GCA）来评估有效连接。在双变量模式下计算 ROI 之间的有符号路径系数。
在 AUD 患者中，DAN 中的左侧顶上回（SPG）和左侧顶间沟（IPS）的 FC 降低；DMN 中的右侧额上回（SPG）和右侧额中回（MFG）的 FC 降低。GCA 值表明 DMN 对 DAN 具有正因果影响（ = 0.007/0.027），从而对 DMN 产生负因果影响（ = 0.032）。从右侧 MFG 到左侧 IPS 的有符号路径系数与 MAST 评分呈负相关（ = 0.015）。
我们发现 AUD 患者存在新的网络间连接功能障碍，表明静息状态下 DAN 和 DMN 之间存在异常的因果关系。因此，AUD 患者可能存在异常的自上而下的注意力调节和认知功能。
