Zhang Lindy, Thornton Clifton P, Ruble Kathy, Cooper Stacy L
Johns Hopkins University, Baltimore, MD, USA.
National Institutes of Health, Bethesda, MD, USA.
Clin Pediatr (Phila). 2020 Jun;59(6):606-613. doi: 10.1177/0009922820915884.
. To evaluate the strategy of checking vaccine titers after completion of chemotherapy. . Retrospective review of pediatric oncology patients who completed chemotherapy. Demographics, post-chemotherapy titers, and absolute lymphocyte counts (ALCs) were analyzed. . Ninety patients met inclusion criteria, and 87% of patients had at least one titer checked. Comparing patients <7 years and those ≥7 years at diagnosis, there was no difference in incidence of negative titers except mumps; those <7 years old were more likely to have negative titers (58% vs 20%, = .003). Comparing those <13 years old to ≥13 years old, there was no difference in negative titers except mumps (45% vs 19%, = .02) and tetanus (44% vs 0%, = .002). No patient maintained all protective titers after completion of chemotherapy. Time to ALC recovery was not predictive of positive titers. . Checking titers after chemotherapy is not recommended. Providers should assume loss of immunity.
评估化疗结束后检查疫苗滴度的策略。
对完成化疗的儿科肿瘤患者进行回顾性研究。分析人口统计学数据、化疗后滴度以及绝对淋巴细胞计数（ALC）。
90名患者符合纳入标准，87%的患者至少检查了一种滴度。比较诊断时年龄<7岁和≥7岁的患者，除腮腺炎外，阴性滴度发生率无差异；<7岁的患者更易出现阴性滴度（58%对20%，P = 0.003）。比较<13岁和≥13岁的患者，除腮腺炎（45%对19%，P = 0.02）和破伤风（44%对0%，P = 0.002）外，阴性滴度无差异。化疗结束后没有患者维持所有保护性滴度。ALC恢复时间不能预测阳性滴度。
不建议化疗后检查滴度。医疗人员应假定免疫力丧失。
