在动物模型中模拟人类的抗菌方案：透明度和验证至关重要。
Human-Simulated Antimicrobial Regimens in Animal Models: Transparency and Validation Are Imperative.
机构信息
Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA.
Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut, USA
出版信息
Antimicrob Agents Chemother. 2020 Jul 22;64(8). doi: 10.1128/AAC.00594-20.
Abstract
Animal infection models are invaluable in optimizing antimicrobial dosage in humans. Utilization of human-simulated regimens (HSRs) in animal models helps to evaluate antimicrobial efficacy at clinically achievable drug concentrations. To that end, pharmacokinetic studies in infected animals and confirmation of the HSR pharmacokinetic profile are essential in evaluating observed versus expected drug concentrations. We present and compare two murine meropenem-vaborbactam HSR profiles, their potential impact on bacterial killing, and clinical translatability.
摘要
动物感染模型在优化人类抗菌药物剂量方面具有不可估量的价值。在动物模型中使用模拟人体的方案（HSR）有助于评估在临床可达到的药物浓度下的抗菌疗效。为此，在感染动物中进行药代动力学研究并确认 HSR 的药代动力学特征对于评估观察到的与预期的药物浓度至关重要。我们提出并比较了两种鼠类美罗培南-沃博巴坦 HSR 特征，及其对细菌杀伤的潜在影响和临床转化性。
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