Edmiston E Kale, Song Yanzhuo, Chang Miao, Yin Zhiyang, Zhou Qian, Zhou Yifang, Jiang Xiaowei, Wei Shengnan, Xu Ke, Tang Yanqing, Wang Fei
Brain Function Research Section, The First Affiliated Hospital of China Medical University, Shenyang, China.
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Front Psychiatry. 2020 May 4;11:278. doi: 10.3389/fpsyt.2020.00278. eCollection 2020.
The hippocampus is an important candidate region in the study of functional connectivity alterations in schizophrenia (SZ) given its role as a functional hub for multiple brain networks. Although studies have implicated the hippocampus in SZ, no studies have compared hippocampal functional connectivity in healthy participants, patients with SZ, and unaffected family members (UAFMs). Patients and UAFM likely share biomarkers associated with susceptibility to SZ; the study of UAFM may also reveal compensatory markers. Patients with SZ, UAFM, and healthy control (HC) participants underwent resting state magnetic resonance imagingty and completed the Wisconsin Card Sort Task (WCST) as a measure of general cognitive function. We compared functional coupling with a hippocampus seed across the three groups. SZ and UAFM groups shared reductions in connectivity between the hippocampus and the striatum relative to HC. We also identified a significant positive correlation between WCST errors and hippocampal-striatal connectivity in the UAFM group. Hippocampal-striatal rsFC may be associated with familial susceptibility to SZ and with subtle cognitive deficits in the UAFM of individuals with SZ.
鉴于海马体作为多个脑网络的功能枢纽，它是精神分裂症（SZ）功能连接改变研究中的一个重要候选区域。尽管已有研究表明海马体与精神分裂症有关，但尚无研究比较健康参与者、精神分裂症患者和未患病家庭成员（UAFM）的海马体功能连接情况。患者和UAFM可能共享与精神分裂症易感性相关的生物标志物；对UAFM的研究也可能揭示代偿性标志物。精神分裂症患者、UAFM和健康对照（HC）参与者接受了静息态磁共振成像检查，并完成了威斯康星卡片分类任务（WCST），作为一般认知功能的一项测量。我们比较了三组中与海马体种子点的功能耦合情况。与HC相比，SZ组和UAFM组海马体与纹状体之间的连接性均降低。我们还发现UAFM组中WCST错误与海马体-纹状体连接性之间存在显著正相关。海马体-纹状体静息态功能连接（rsFC）可能与精神分裂症的家族易感性以及SZ患者UAFM中的细微认知缺陷有关。
