Hartveit F, Maehle B O
Department of Pathology, Gade Institute, University of Bergen, Norway.
Breast Cancer Res Treat. 1988 Oct;12(2):205-11. doi: 10.1007/BF01805941.
A new method of characterizing breast carcinomas is presented that may help further our understanding of this disease. A tumour age coefficient is described, derived from tumour diameter and the mean nuclear area of the tumour cells, the latter a measure of tumour growth rate. On this basis a series of 213 operative infiltrating breast carcinomas is divided into 3 tumour age groups (young, old, and very old). These are then related to axillary nodal status and the patient's age at operation. The likelihood of nodal spread is shown to increase with tumour age. This is interpreted as an expression of a build-up of tumours that have spread with time. There was no set tumour age by which metastatic spread could be expected, but some indication of a lower age limit.
本文提出了一种表征乳腺癌的新方法，这可能有助于进一步加深我们对这种疾病的理解。文中描述了一种肿瘤年龄系数，它由肿瘤直径和肿瘤细胞的平均核面积得出，后者是肿瘤生长速率的一种度量。在此基础上，将一组213例手术切除的浸润性乳腺癌分为3个肿瘤年龄组（年轻、年老和非常年老）。然后将这些分组与腋窝淋巴结状态及患者手术时的年龄相关联。结果显示，淋巴结转移的可能性随肿瘤年龄增加而增大。这被解释为肿瘤随时间推移发生转移的一种表现。不存在一个可预期发生转移扩散的固定肿瘤年龄，但有一些迹象表明存在一个下限年龄。
