Kovács Petra Terézia, Juhász Dániel, Módos Orsolya, Kocsmár Ildikó, Terebessy András, Lotz Gábor, Szarvas Tibor, Nyirády Péter, Riesz Péter
Általános Orvostudományi Kar, Urológiai Klinika,Semmelweis Egyetem Budapest, Üllői út 26., 1085.
Általános Orvostudományi Kar, II. Patológiai Intézet,Semmelweis Egyetem Budapest.
Orv Hetil. 2020 May;161(21):881-888. doi: 10.1556/650.2020.31709.
Urothelial cancer can develop in the renal pelvis, ureters, bladder and the proximal urethra as urothelial tissue can be found in these organs. Upper tract urothelial carcinoma is rare but better understanding of the natural history of the disease is important because bladder recurrence often occurs after radical nephroureterectomy.
Our retrospective study aims to describe the general characteristics of patients treated with radical nephroureterectomy at the Department of Urology, Semmelweis University, between January 1st, 2005 and December 31st, 2016. Additionally, we aimed to identify risk factors of bladder recurrence after radical surgery.
160 patients had radical nephroureterectomy and 135 of them had urothelial upper urinary tract cancer. The mean follow-up period was 32 months (SD: 30.25), bladder recurrence was diagnosed at 31 patients (23%), the average time for the recurrence was 19.6 months (SD: 29.7). Recurrence occurred significantly earlier among older patients (p = 0.007) and it was also associated with hypertonia of the patients (p = 0.035).
Upper tract urothelial cancer recurrence occurs earlier among older and multimorbid patients. Careful watching of these patients (frequent reminder to regular cystoscopy and control examinations) could reduce further complications. Orv Hetil. 2020; 161(21): 881-888.
肾盂、输尿管、膀胱及尿道近端均可发生尿路上皮癌，因为这些器官中存在尿路上皮组织。上尿路尿路上皮癌较为罕见，但更好地了解该疾病的自然史很重要，因为根治性肾输尿管切除术后膀胱复发很常见。
我们的回顾性研究旨在描述2005年1月1日至2016年12月31日期间在塞梅尔维斯大学泌尿外科接受根治性肾输尿管切除术患者的一般特征。此外，我们旨在确定根治性手术后膀胱复发的危险因素。
160例患者接受了根治性肾输尿管切除术，其中135例患有上尿路尿路上皮癌。平均随访期为32个月（标准差：30.25），31例患者（23%）被诊断为膀胱复发，复发的平均时间为19.6个月（标准差：29.7）。老年患者的复发明显更早（p = 0.007），且复发也与患者的高血压有关（p = 0.035）。
老年和多病患者的上尿路尿路上皮癌复发更早。对这些患者进行密切观察（经常提醒进行定期膀胱镜检查和对照检查）可以减少进一步的并发症。《匈牙利医学周报》。2020年；161(21): 881 - 888。
