Shanghai Advanced Research Institute.
Shanghai Institute of Materia Medica.
Neuroreport. 2020 Jul 10;31(10):697-701. doi: 10.1097/WNR.0000000000001348.
Besides degradation, lysosomes can also carry molecules for secretion out of the cell, such as ATP and cytokines, during unconventional secretion. Phosphatidylinositols and their metabolizing enzymes play important roles in the sorting and trafficking of lysosomal materials through the trans-Golgi network. The present study reveals a new function of phosphatidylinositol kinase-III alpha in the 'kiss-and-run' fusion of lysosomes at the plasma membrane to release ATP from microglia.
除了降解作用，溶酶体还可以在非典型分泌过程中将分子分泌到细胞外，如 ATP 和细胞因子。磷脂酰肌醇及其代谢酶在溶酶体物质通过高尔基体内质网的分拣和运输中发挥重要作用。本研究揭示了磷脂酰肌醇激酶-IIIα在微胶质细胞的溶酶体与质膜“亲吻-跑开”融合以释放 ATP 中的新功能。
