Papadopoli Rosa, De Sarro Caterina, Torti Carlo, Pileggi Claudia, Pavia Maria
Department of Health Sciences, University of Catanzaro "Magna Græcia", Campus Universitario "Salvatore Venuta", Viale Europa, 88100 Catanzaro, Italy.
Department of Medical and Surgical Sciences, University of Catanzaro "Magna Græcia", Campus Universitario "Salvatore Venuta", Viale Europa, 88100 Catanzaro, Italy.
Vaccines (Basel). 2020 May 16;8(2):227. doi: 10.3390/vaccines8020227.
Whether the primary Hepatitis B vaccination confers lifelong protection is debated. The aim of the study was to assess the effectiveness of booster doses in mounting a protective HBV immune response in subjects vaccinated 18-20 years earlier. The study population consisted of vaccinated students attending medical and healthcare professions schools. A booster dose was offered to subjects with a <10 mIU/mL anti-HBs titer. The post-booster anti-HBs titer was evaluated after four weeks. The subjects with a <10 mIU/mL post-booster anti-HBs titer, received a second and third dose of the vaccine and after one month they were retested. A <10 mIU/mL anti-HBs titer was found in 35.1% of the participants and 92.2% of subjects that were boosted had a ≥10 mIU/mL post-booster anti-HBs titer, whereas 7.8% did not mount an anamnestic response. A low post-booster response (10-100 mIU/mL anti-HBs) was significantly more likely in subjects with a <2.00 mIU/mL pre-booster titer compared to those with a 2.00-9.99 mIU/mL pre-booster titer. The anamnestic response was significantly related to the baseline anti-HBs levels. A booster dose of the HBV vaccine may be insufficient to induce an immunological response in subjects with undetectable anti-HBs titers. A booster dose might be implemented when an anamnestic response is still present.
乙肝初种疫苗是否能提供终身保护存在争议。本研究的目的是评估加强剂量疫苗对18至20年前接种疫苗的受试者产生保护性乙肝病毒免疫反应的有效性。研究人群包括就读于医学和医疗保健专业学校的已接种疫苗的学生。抗-HBs滴度<10 mIU/mL的受试者接种一剂加强疫苗。四周后评估加强疫苗接种后的抗-HBs滴度。抗-HBs滴度<10 mIU/mL的受试者接受第二剂和第三剂疫苗接种，一个月后重新检测。35.1%的参与者抗-HBs滴度<10 mIU/mL，92.2%接种加强疫苗的受试者加强疫苗接种后的抗-HBs滴度≥10 mIU/mL，而7.8%未产生回忆反应。加强疫苗接种后反应较低（抗-HBs为10 - 100 mIU/mL）的受试者中，加强疫苗接种前滴度<2.00 mIU/mL的受试者比加强疫苗接种前滴度为2.00 - 9.99 mIU/mL的受试者更显著。回忆反应与基线抗-HBs水平显著相关。乙肝疫苗加强剂量可能不足以在抗-HBs滴度检测不到的受试者中诱导免疫反应。当仍存在回忆反应时可实施加强剂量接种。
