Department of Human Studies, University of Ferrara, via Paradiso, 12, 44100 Ferrara, Italy.
Int J Environ Res Public Health. 2020 May 17;17(10):3507. doi: 10.3390/ijerph17103507.
The study of the development of neonatal pain responses is of key importance, both for research and for clinical reasons, with particular regard to the population of preterm neonates, given the amount of painful procedures they are exposed to on a daily basis. The aim of this work was to systematize our knowledge about the development of pain responses in prematurely born neonates by focusing on some key methodological issues. Studies on the impact of age variables, namely gestational age (GA), postmenstrual age (PMA) and chronological age (CH), on pain responsivity in premature neonates were identified using Medline and Scopus. Studies ( = 42) were categorized based on terminological and methodological approaches towards age variables, and according to output variables considered (facial, nonfacial behavioral, physiological). Distinct multidimensional developmental patterns were found for each age-sampling strategy. Overall, each of the three age variables seems to affect pain responsivity, possibly differently across age windows. Targeted as well as integrated approaches, together with a renewed attention for methodological consistency, are needed to further our knowledge on this topic.
研究新生儿疼痛反应的发展至关重要，无论是出于研究还是临床原因，对于早产儿这一人群尤其如此，因为他们每天都要接受大量的疼痛处理。本研究的目的是通过关注一些关键的方法学问题，系统地了解早产儿疼痛反应的发展。我们使用 Medline 和 Scopus 确定了关于年龄变量（即胎龄（GA）、月经后年龄（PMA）和年龄（CH））对早产儿疼痛反应影响的研究。根据术语和方法学方法以及考虑的输出变量（面部、非面部行为、生理）对研究（n = 42）进行分类。对于每种年龄采样策略，都发现了不同的多维发育模式。总体而言，这三个年龄变量中的每一个似乎都影响疼痛反应，可能在不同的年龄窗口中有所不同。需要有针对性和综合性的方法，以及对方法一致性的重新关注，以进一步了解这一主题。
