Pol J Pathol. 2020;71(1):30-37. doi: 10.5114/pjp.2020.95413.
Most neuroendocrine neoplasms (NEN) are characterized by the presence of somatostatin receptors (SSTR) which we use in location diagnostics and treatment. The aim of this study was to evaluate the expression of somatostatin receptors by immunohistochemistry in tissue obtained after surgery of the primary focus in the small intestine. The group of patients consisted of 41 people, in 18 cases the primary tumor was in the jejunum and in 23 in the ileum. The immunohistochemical method was used to visualize the receptors, using polyclonal antibodies in a two-stage peroxidase method. In patients with NEN of the small intestine, the SSTR2a and SSTR5 receptors are most commonly expressed, followed by SSTR2b and 3. In statistical analysis, it was shown that the expression of somatostatin receptors was not dependent on the primary site of the tumor (p > 0.05). The dependence of SSTR expression on histological maturity is evident. SSTR1, SSTR2b, SSTR3 and SSTR5 are more common in tumors with grading G1 (p < 0.05). In the study group, the exception was SSTR2a, whose incidence was comparable in both groups (p = 0.35). In NEN of the small intestine, the expression SSTR2a and SSTR5 is the most common.
大多数神经内分泌肿瘤（NEN）的特征是存在生长抑素受体（SSTR），我们利用这些受体进行定位诊断和治疗。本研究的目的是通过免疫组织化学评估小肠原发性病灶手术后获得的组织中生长抑素受体的表达。患者组由41人组成，其中18例原发性肿瘤位于空肠，23例位于回肠。采用免疫组织化学方法，利用多克隆抗体通过两步过氧化物酶法使受体可视化。在小肠NEN患者中，SSTR2a和SSTR5受体表达最为常见，其次是SSTR2b和SSTR3。统计分析表明，生长抑素受体的表达不依赖于肿瘤的原发部位（p>0.05）。SSTR表达与组织学成熟度之间的相关性明显。SSTR1、SSTR2b、SSTR3和SSTR5在G1级肿瘤中更为常见（p<0.05）。在研究组中，SSTR2a是个例外，其发生率在两组中相当（p=0.35）。在小肠NEN中，SSTR2a和SSTR5的表达最为常见。
