Terui N, Saeki Y, Kumada M
Institute of Basic Medical Sciences, University of Tsukuba, Japan.
Clin Exp Hypertens A. 1988;10 Suppl 1:269-74. doi: 10.3109/10641968809075979.
In urethane-anesthetized and vagotomized rabbits, activation of C-fibers of renal afferents resulted in a reflex change in multifiber renal nerve activity (RNA) which consisted of inhibitory (I) and excitatory (E) components, either alone or in combination. The I and E components were individually and reversibly blocked by bilateral application of bicuculline and kynurenic acid, respectively, to the ventral surface of medulla. Bicuculline further eliminated the sympathoinhibiton produced by stimulation of the aortic nerve. Within the subjacent rostral ventrolateral medulla (RVLM), we recorded 23 spontaneously active single units that responded to electrical stimulation of renal afferents and were antidromically activated by stimulation of the dorsolateral funiculus at the C2 level. Usually, the neuronal response preceded that of the RNA by about 100 ms. These bulbospinal RVLM neurons were barosensory, since they responded to stimulation of the aortic nerve. We conclude that barosensory neurons in the RVLM mediate the renal-sympathetic reflex in rabbits.
在氨基甲酸乙酯麻醉并切断迷走神经的家兔中，肾传入神经C纤维的激活导致多纤维肾神经活动（RNA）出现反射性变化，该变化由抑制性（I）和兴奋性（E）成分单独或联合组成。通过将荷包牡丹碱和犬尿氨酸分别双侧应用于延髓腹面，可分别单独且可逆地阻断I和E成分。荷包牡丹碱进一步消除了刺激主动脉神经所产生的交感神经抑制。在相邻的延髓头端腹外侧区（RVLM），我们记录到23个自发活动的单个单位，它们对肾传入神经的电刺激有反应，并在C2水平被背外侧索刺激逆向激活。通常，神经元反应比RNA反应提前约100毫秒。这些延髓脊髓RVLM神经元具有压力感受性，因为它们对主动脉神经的刺激有反应。我们得出结论，RVLM中的压力感受性神经元介导家兔的肾交感反射。
