Takeda K, Nakamura Y, Hayashi J, Kawasaki S, Nakata T, Oguro M, Sasaki S, Nakagawa M
Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Clin Exp Hypertens A. 1988;10 Suppl 1:289-99. doi: 10.3109/10641968809075982.
Cardiovascular and sympathetic nerve responses to electrical stimulation of either the aortic depressor nerve (ADN) or the posterior hypothalamus were recorded from rats treated with salt, DOCA, or DOCA/salt and compared with those from untreated controls. By the 7th day, tail-cuff systolic pressures were significantly elevated in rats treated with salt or DOCA/salt. And by the 21st day, all treated rats (i.e. with salt, DOCA, or DOCA/salt) had elevated pressures together with attenuated ADN responses and augmented hypothalamic responses. After 5 days, DOCA/salt treated rats already had attenuated responses to ADN stimulation and augmented responses to hypothalamic stimulation even though their systolic pressures were still unaltered. These findings suggest that combined treatment with salt and DOCA altered central blood pressure regulation even before hypertension developed.
记录了用盐、去氧皮质酮（DOCA）或DOCA/盐处理的大鼠对主动脉减压神经（ADN）或下丘脑后部进行电刺激时的心血管和交感神经反应，并与未处理的对照大鼠进行比较。到第7天，用盐或DOCA/盐处理的大鼠尾袖收缩压显著升高。到第21天，所有处理过的大鼠（即用盐、DOCA或DOCA/盐处理的大鼠）血压升高，同时ADN反应减弱，下丘脑反应增强。5天后，DOCA/盐处理的大鼠对ADN刺激的反应已经减弱，对下丘脑刺激的反应增强，尽管它们的收缩压仍未改变。这些发现表明，在高血压发生之前，盐和DOCA联合处理就改变了中枢血压调节。
