罗米司亭治疗产后即刻难治性免疫性血小板减少性紫癜。
Romiplostim for management of refractory immune thrombocytopenic purpura in the immediate postpartum period.
机构信息
Department of OB/GYN, Trinity Health of New England, Hartford, Connecticut, USA.
Department of Nephrology, Trinity Health of New England, Mercy Medical Center, Springfield, Massachusetts, USA.
出版信息
BMJ Case Rep. 2020 May 18;13(5):e234335. doi: 10.1136/bcr-2020-234335.
Abstract
We present a case of a pregnant woman with chronic immune thrombocytopenic purpura and chronic hypertension who developed pre-eclampsia with severe features warranting delivery. Her overall clinical picture and liver enzymes improved in the immediate postpartum period, however, aggressively progressing thrombocytopenia posed a diagnostic dilemma to the interdisciplinary care team. After failing to respond to first-line therapies including high-dose corticosteroids and intravenous immunoglobulin, she was successfully managed with a trial of the thrombopoietin receptor agonist, Romiplostim.
摘要
我们报告了一例患有慢性免疫性血小板减少性紫癜和慢性高血压的孕妇，她发展为重度子痫前期，需要分娩。她的整体临床情况和肝酶在产后即刻得到改善，然而，进行性加重的血小板减少对多学科护理团队构成了诊断难题。一线治疗包括大剂量皮质类固醇和静脉注射免疫球蛋白，但均无效，随后她成功接受了血小板生成素受体激动剂罗米司亭治疗。
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