McVicar A J
Division of Physiology, United Medical School, London, UK.
Diabetes Res. 1988 Nov;9(3):139-43.
Conscious male rats received an infusion of glucose in saline (139 mM glucose in 77 mM sodium chloride at 5.2 ml/h) via a tail vein for up to 7 h. A control group of rats received saline alone. Rats of both groups were of similar body weights. Plasma glucose concentration averaged 4.9 +/- 0.4 mmol/l (mean + SEM, n = 5) after 4 h saline infusion and 12.9 +/- 0.2 mmol/l (n = 5; difference, p less than 0.001, paired t-test) after 4 h of combined glucose and saline infusion. Urinary glucose excretion was similar in both groups. Urine flow rate and sodium excretion rate were similar in both groups during the infusions. Calculation of the cumulative changes in sodium balance indicated that both groups of rats returned to sodium balance after about 4 h of infusion and remained so for the subsequent 3 h. Values for plasma protein concentration and plasma osmolality were not significantly different after 4 h of either infusion. Inulin clearance during the 4-6 h period of saline infusion (= 3.40 +/- 0.23 ml/min) was not significantly different to that during the 2-4 h period (= 3.33 +/- 0.20 ml/min). In rats infused with glucose in saline inulin clearance increased significantly during the 4-6 h period compared with that during the 2-4 h period (4.14 +/- 0.32 vs 3.31 +/- 0.32 ml/min, p less than 0.05 paired t-test). Mean arterial blood pressure was similar in the two groups of rats and did not change significantly during the experiment.(ABSTRACT TRUNCATED AT 250 WORDS)
清醒的雄性大鼠通过尾静脉接受葡萄糖盐水输注（139 mM葡萄糖溶于77 mM氯化钠，输注速度为5.2 ml/h），持续7小时。对照组大鼠仅接受生理盐水输注。两组大鼠体重相似。生理盐水输注4小时后，血浆葡萄糖浓度平均为4.9±0.4 mmol/l（平均值±标准误，n = 5），葡萄糖和生理盐水联合输注4小时后，血浆葡萄糖浓度为12.9±0.2 mmol/l（n = 5；差异，p<0.001，配对t检验）。两组的尿糖排泄相似。输注期间，两组的尿流率和钠排泄率相似。钠平衡累积变化的计算表明，两组大鼠在输注约4小时后恢复钠平衡，并在随后的3小时内保持平衡。两种输注4小时后，血浆蛋白浓度和血浆渗透压值无显著差异。生理盐水输注4 - 6小时期间的菊粉清除率（= 3.40±0.23 ml/min）与2 - 4小时期间（= 3.33±0.20 ml/min）无显著差异。在葡萄糖盐水输注的大鼠中，4 - 6小时期间的菊粉清除率与2 - 4小时期间相比显著增加（4.14±0.32对3.31±0.32 ml/min，p<0.05，配对t检验）。两组大鼠的平均动脉血压相似，且在实验期间无显著变化。（摘要截短至250字）
